Hyperchloremic acidosis

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Hyperchloremic acidosis is a form of metabolic acidosis associated with a normal anion gap, a decrease in plasma bicarbonate concentration, and in an increase in plasma chloride concentration (see anion gap for a fuller explanation).

Causes

• Renal tubular acidosis failure of HCO₃^- resorption(i.e. proximal renal tubular acidosis) or failure of H⁺ secretion (ie in distal renal tubular acidosis)
• Renal failure
• Gastrointestinal loss of HCO₃^- with diarrhea (vomiting will tend to cause hypochloraemic alkalosis).
• Ingestions
  • Ammonium chloride, Hydrochloric acid
  • Hyperalimentation fluids (i.e. total parenteral nutrition)

• Alcohol (such as ethanol) can effect anion gap by inducing alcohol dehydrogenase enzyme.

See also

• Anion gap
• Metabolic acidosis

External links

• Template:FPnotebook
• Template:DiseasesDB
• NIH - Renal Tubular Acidosis