Atrial septal defect anatomy: Difference between revisions
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==Anatomy== | ==Anatomy== | ||
The development of heart in fetal life takes place as early as 4th week of gestation. An abnormal septal development at this stage may lead to atrial septal defect. The sequence of changes that happen during normal embryogenesis | The development of [[heart]] in fetal life takes place as early as 4th week of gestation. An abnormal septal development at this stage may lead to [[atrial septal defect]]. The sequence of changes that happen during normal septal embryogenesis in heart development are as follow- | ||
'''1.''' The developing heart has an orifice called ostium primum between the atrium. | '''1.''' The developing heart has an orifice called '''ostium primum''' between the [[atrium]]. | ||
'''2.''' A septum primum arises from the superior portion of the common atrium of the developing heart. | '''2.''' A '''septum primum''' arises from the superior portion of the common atrium of the developing heart. | ||
'''3.''' An endocardial cushion is located between the atria and ventricles | '''3.''' An '''endocardial cushion''' is located between the [[atria]] and [[ventricles]] | ||
'''4.''' Septum primum grows downward to the endocardial cushions. This leads to the closing of the orifice (ostium primum) between the atria. | '''4.''' Septum primum grows downward to the endocardial cushions. This leads to the closing of the orifice (ostium primum) between the atria. | ||
'''5.''' A second orifice (the ostium secundum) develops in the septum primum. This second orifice gets covered with septum secundum. However, the septum secundum doesn’t close the ostium secundum completely and this leads to an orifice called the foramen ovale | '''5.''' A '''second orifice (the ostium secundum)''' develops in the septum primum. This second orifice gets covered with '''septum secundum'''. However, the septum secundum doesn’t close the ostium secundum completely and this leads to an orifice called the '''foramen ovale''' | ||
'''6.''' In the fetus this orifice allows shunting of blood from right to left side of the heart. This is so because during the fetus life right side heart pressures are more than the systemic pressure. However, there is a reversal of pressure gradient after birth (systemic pressures becomes more than right sided pressure) and this change of pressure causes the septum primum to be held against the septum secundum and ceasing of the interatrial shunt | '''6.''' In the fetus this orifice allows shunting of blood from right to left side of the heart. This is so because during the fetus life right side heart pressures are more than the systemic pressure. However, there is a reversal of pressure gradient after birth (systemic pressures becomes more than right sided pressure) and this change of pressure causes the septum primum to be held against the septum secundum and ceasing of the interatrial shunt | ||
Revision as of 14:34, 19 August 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [[2]]; Cafer Zorkun, M.D., Ph.D. [3]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [[4]]
Overview
Anatomy
The development of heart in fetal life takes place as early as 4th week of gestation. An abnormal septal development at this stage may lead to atrial septal defect. The sequence of changes that happen during normal septal embryogenesis in heart development are as follow-
1. The developing heart has an orifice called ostium primum between the atrium.
2. A septum primum arises from the superior portion of the common atrium of the developing heart.
3. An endocardial cushion is located between the atria and ventricles
4. Septum primum grows downward to the endocardial cushions. This leads to the closing of the orifice (ostium primum) between the atria.
5. A second orifice (the ostium secundum) develops in the septum primum. This second orifice gets covered with septum secundum. However, the septum secundum doesn’t close the ostium secundum completely and this leads to an orifice called the foramen ovale
6. In the fetus this orifice allows shunting of blood from right to left side of the heart. This is so because during the fetus life right side heart pressures are more than the systemic pressure. However, there is a reversal of pressure gradient after birth (systemic pressures becomes more than right sided pressure) and this change of pressure causes the septum primum to be held against the septum secundum and ceasing of the interatrial shunt