Deep vein thrombosis risk factors: Difference between revisions
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*Acquired disorders | *Acquired disorders | ||
** A previous history of DVT (most significant risk factor).According to a study done by | ** A previous history of DVT (most significant risk factor).According to a study done by Cushman et al, a 28-day case-fatality rate of 9.4% after first-time DVT and 15.1% after first-time PE.<ref name="pmid15210384">{{cite journal| author=Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P et al.| title=Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. | journal=Am J Med | year= 2004 | volume= 117 | issue= 1 | pages= 19-25 | pmid=15210384 | doi=10.1016/j.amjmed.2004.01.018 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15210384 }} </ref> | ||
** Injury to a deep vein from surgery, fractured bone, or other trauma. | ** Injury to a deep vein from surgery, fractured bone, or other trauma. | ||
** Prolong Immobilization : It slow down the blood flow in a deep vein. This may occur after surgery, if you're ill and in bed for a long time, or if you're on a long flight. | ** Prolong Immobilization : It slow down the blood flow in a deep vein. This may occur after surgery, if you're ill and in bed for a long time, or if you're on a long flight. | ||
Revision as of 19:43, 29 August 2011
Editors-in-Chief: C. Michael Gibson, M.S., M.D. Associate Editor-In-Chief: Ujjwal Rastogi, MBBS [1]
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Overview
The presence or an absence of a risk factor plays a major role in the assessment of the pretest probability of DVT. Furthermore,
- Short-term anticoagulation is reruired for transient risk factors.
- Long-term anticoagulation is given where the cause is unknown or chronic or presence of persistent risk factors.
Risk factors:Inherited vs Acquired
Risk factors can be broadly classified in two categories, which are:
- Inherited thrombophilia: which include the following disorder
- Factor V Leiden mutation
- Prothrombin gene mutation
- Protein S deficiency
- Protein C deficiency
- Antithrombin (AT) deficiency
- Acquired disorders
- A previous history of DVT (most significant risk factor).According to a study done by Cushman et al, a 28-day case-fatality rate of 9.4% after first-time DVT and 15.1% after first-time PE.[1]
- Injury to a deep vein from surgery, fractured bone, or other trauma.
- Prolong Immobilization : It slow down the blood flow in a deep vein. This may occur after surgery, if you're ill and in bed for a long time, or if you're on a long flight.
- Pregnancy and the first 6 weeks after giving birth.
- Recent or ongoing treatment for cancer.
- A central venous catheter, a tube placed in vein to allow easy access to the bloodstream for medical treatment.
- Age>60 (although DVT can occur in any age group).
- Being overweight or obese.[2]
References
- ↑ Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P; et al. (2004). "Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology". Am J Med. 117 (1): 19–25. doi:10.1016/j.amjmed.2004.01.018. PMID 15210384.
- ↑ Eichinger S, Hron G, Bialonczyk C, Hirschl M, Minar E, Wagner O; et al. (2008). "Overweight, obesity, and the risk of recurrent venous thromboembolism". Arch Intern Med. 168 (15): 1678–83. doi:10.1001/archinte.168.15.1678. PMID 18695082.