Time in therapeutic range

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and Keywords: TTR

Factors Affecting Time in Therapeutic Range (TTR)

Cross trial comparisons of TTR are hampered by variations in:

CHADS Score

A higher CHADS score is associated with a lower TTR. Sicker patients may have reduced access to frequent testing.

Congestive Heart Failure (CHF)

The presence of congestive heart failure Varying drug clearance and distribution (CHF: 63% in ROCKET, 32% RELY, 35% ARISTOTLE)

• Country: Highest in Scandanavia, lowest in developing countries

• What is the TTR in ROCKET AF in those countries who conducted RE-LY and vice versa (adjusting for the number of sites in each country)?

• Should trials only be conducted in countries with a high TTR or should sponsors conduct real world trials throughout the world?