Asthma in pregnancy: Difference between revisions
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==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
Asthma during pregnancy may have negative impact on both mother and the child especially in severe or poorly controlled cases. Complications include: | Severe or poorly controlled asthma cause maternal [[hypoxia]], [[hypercapnia]] and [[respiratory alkalosis]] which may impair fetal oxygenation and uteroplacental blood flow. Asthma during pregnancy may have negative impact on both mother and the child especially in severe or poorly controlled cases. Complications include: | ||
*Complications during [[labor]]<ref name="pmid11174486">{{cite journal| author=Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS| title=Maternal asthma and pregnancy outcomes: a retrospective cohort study. | journal=Am J Obstet Gynecol | year= 2001 | volume= 184 | issue= 2 | pages= 90-6 | pmid=11174486 | doi=10.1067/mob.2001.108073 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11174486 }} </ref> | *Complications during [[labor]]<ref name="pmid11174486">{{cite journal| author=Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS| title=Maternal asthma and pregnancy outcomes: a retrospective cohort study. | journal=Am J Obstet Gynecol | year= 2001 | volume= 184 | issue= 2 | pages= 90-6 | pmid=11174486 | doi=10.1067/mob.2001.108073 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11174486 }} </ref> | ||
*Congenital anomalies | *Congenital anomalies | ||
Revision as of 20:22, 27 September 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]
Overview
Asthma is one of the most common pulmonary conditions occurring during pregnancy[1] with a prevalence rate of 3.7% to 8.4% in United States during the period 1997-2001[2].
Pathophysiology
During pregnancy, due to high levels of progesterone, minute ventilatory rate is increased causing compensated respiratory alkalosis.[3] Hence the arterial blood gases may reveal a higher PO2 and lower PCO2 with mild alkalotic PH. Normal PCO2 during pregnancy is suggestive of impending respiratory failure.
Asthma is characterized by broncho-constriction or inflammation of airways with production of thick mucoid secretions. In a small prospective study involving 16 asthmatic pregnant women, hyper-reactivity was seen to be lower as evidenced by a reduction in minimum medication requirements.[4]
Natural History, Complications and Prognosis
Severe or poorly controlled asthma cause maternal hypoxia, hypercapnia and respiratory alkalosis which may impair fetal oxygenation and uteroplacental blood flow. Asthma during pregnancy may have negative impact on both mother and the child especially in severe or poorly controlled cases. Complications include:
- Complications during labor[5]
- Congenital anomalies
- Complications of corticosteroid use[6]
- Cesarean delivery[5]
- Hyperemesis
- Hypertensive conditions[7][5]
- Low birth weight infants[5][8]
- Neonatal hypoglycemia
- Neonatal mortality
- Neonatal seizures
- Preterm labor and premature delivery[5][8]
- Preeclampsia[9]
- Respiratory failure
- Uterine hemorrhage
Treatment [4]
- Monitor asthma control during all prenatal visits.
- Asthmatic symptoms worsen in about a third during pregnancy and improve in a third; hence, medications should be adjusted accordingly.
- Regular monitoring and maintenance of lung function to ensure adequate oxygen supply to the fetus.
- It is safer to treat asthma with medications than to have poorly-controlled asthma.
- Drug of choice in pregnancy:
- Albuterol is preferred to short-acting β2-agonist (SABA)
- Inhaled corticosteroid such as budesonide is preferred for long-term control of symptoms.
References
- ↑ Rey E, Boulet LP (2007). "Asthma in pregnancy". BMJ. 334 (7593): 582–5. doi:10.1136/bmj.39112.717674.BE. PMC 1828355. PMID 17363831.
- ↑ Kwon HL, Belanger K, Bracken MB (2003). "Asthma prevalence among pregnant and childbearing-aged women in the United States: estimates from national health surveys". Ann Epidemiol. 13 (5): 317–24. PMID 12821270.
- ↑ Wise RA, Polito AJ, Krishnan V (2006). "Respiratory physiologic changes in pregnancy". Immunol Allergy Clin North Am. 26 (1): 1–12. doi:10.1016/j.iac.2005.10.004. PMID 16443140.
- ↑ Juniper EF, Daniel EE, Roberts RS, Kline PA, Hargreave FE, Newhouse MT (1989). "Improvement in airway responsiveness and asthma severity during pregnancy. A prospective study". Am Rev Respir Dis. 140 (4): 924–31. PMID 2679270.
- ↑ 5.0 5.1 5.2 5.3 5.4 Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS (2001). "Maternal asthma and pregnancy outcomes: a retrospective cohort study". Am J Obstet Gynecol. 184 (2): 90–6. doi:10.1067/mob.2001.108073. PMID 11174486.
- ↑ Perlow JH, Montgomery D, Morgan MA, Towers CV, Porto M (1992). "Severity of asthma and perinatal outcome". Am J Obstet Gynecol. 167 (4 Pt 1): 963–7. PMID 1415433.
- ↑ Lehrer S, Stone J, Lapinski R, Lockwood CJ, Schachter BS, Berkowitz R; et al. (1993). "Association between pregnancy-induced hypertension and asthma during pregnancy". Am J Obstet Gynecol. 168 (5): 1463–6. PMID 8498428.
- ↑ 8.0 8.1 Breton MC, Beauchesne MF, Lemière C, Rey E, Forget A, Blais L (2009). "Risk of perinatal mortality associated with asthma during pregnancy". Thorax. 64 (2): 101–6. doi:10.1136/thx.2008.102970. PMID 19008298.
- ↑ Triche EW, Saftlas AF, Belanger K, Leaderer BP, Bracken MB (2004). "Association of asthma diagnosis, severity, symptoms, and treatment with risk of preeclampsia". Obstet Gynecol. 104 (3): 585–93. doi:10.1097/01.AOG.0000136481.05983.91. PMID 15339773.