Metabolic syndrome dietary therapy: Difference between revisions
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==Trial supportive data== | ==Trial supportive data== | ||
===Meta-analysis on effect of Mediterranean diet on metabolic syndrome=== | ===Meta-analysis on effect of Mediterranean diet on metabolic syndrome <ref name="pmid21392646">{{cite journal| author=Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA, Panagiotakos DB| title=The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. | journal=J Am Coll Cardiol | year= 2011 | volume= 57 | issue= 11 | pages= 1299-313 | pmid=21392646 | doi=10.1016/j.jacc.2010.09.073 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21392646 }} </ref>=== | ||
'''1)''' ''' | '''1)''' '''Source & year''' - J Am Coll Cardiol, 2011 | ||
'''2)''' '''Study | '''2)''' '''Study design''' – [[Meta-analysis]] | ||
'''3)''' '''Study | '''3)''' '''Study question''' - Effect of a Mediterranean diet on [[metabolic syndrome]] and its components. | ||
'''4)''' '''Study results''' - | '''4)''' '''Study Population''' - {50 original research studies (35 clinical trials, 2 prospective and 13 cross-sectional), with 534,906 participants} | ||
'''5)''' '''Study results''' - | |||
* Mediterranean diet was associated with reduced risk of metabolic syndrome (log hazard ratio: -0.69, 95% confidence interval [CI]: -1.24 to -1.16) | * Mediterranean diet was associated with reduced risk of metabolic syndrome (log hazard ratio: -0.69, 95% confidence interval [CI]: -1.24 to -1.16) | ||
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===PREDIMED: Randomized controlled trial on effect of Mediterranean diet on metabolic syndrome <ref name="pmid19064829">{{cite journal| author=Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R et al.| title=Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. | journal=Arch Intern Med | year= 2008 | volume= 168 | issue= 22 | pages= 2449-58 | pmid=19064829 | doi=10.1001/archinte.168.22.2449 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19064829 }} </ref>=== | ===PREDIMED: Randomized controlled trial on effect of Mediterranean diet on metabolic syndrome <ref name="pmid19064829">{{cite journal| author=Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R et al.| title=Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. | journal=Arch Intern Med | year= 2008 | volume= 168 | issue= 22 | pages= 2449-58 | pmid=19064829 | doi=10.1001/archinte.168.22.2449 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19064829 }} </ref>=== | ||
'''1)''' '''Study name''' - PREDIMED (Prevención con Dieta Mediterránea) | '''1)''' '''Source & year''' - Arch Intern Med. 2008 | ||
'''2)''' '''Study name''' - PREDIMED (Prevención con Dieta Mediterránea) | |||
''' | '''3)''' '''Study design''' – Multicenter, 3-arm randomized controlled trial. | ||
''' | '''4)''' '''Study question''' – Determine the efficacy of the MedDiet on the primary prevention of cardiovascular disease | ||
''' | '''5)''' '''Study Population''' – 1224 participant | ||
''' | '''6)''' '''Study period''' – 1 yr | ||
''' | '''7)''' '''Interventions''' - quarterly education about the MedDiet plus provision of either 1 L/wk of virgin olive oil (MedDiet + VOO) or 30 g/d of mixed nuts (MedDiet + nuts), and advice on a low-fat diet (control diet). | ||
''' | '''8)''' '''Study results''' – | ||
• 61.4% of participants met criteria for the [[metabolic syndrome]] | • 61.4% of participants met criteria for the [[metabolic syndrome]] | ||
• One-year prevalence was reduced by 6.7%, 13.7%, and 2.0% in the MedDiet + VOO, MedDiet + nuts, and control diet groups, respectively | • One-year prevalence was reduced by 6.7%, 13.7%, and 2.0% in the MedDiet + VOO, MedDiet + nuts, and control diet groups, respectively | ||
Revision as of 16:48, 29 September 2011
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Metabolic syndrome Microchapters |
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Metabolic syndrome dietary therapy On the Web |
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Risk calculators and risk factors for Metabolic syndrome dietary therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]
Overview
Dietary modifications are the first step in treatment of metabolic syndrome. It can be started in isolation or along with other medications. It helps by assisting in weight loss, thus increasing insulin sensitivity. Studies support that diet, exercise, and drug therapy may inhibit the progression of metabolic syndrome to diabetes mellitus.
Dietary modifications
Findings from various studies suggest that:
1) Westernized and higher fructose diets have increased risk for developing metabolic syndrome.
2) Mediterranean diet rich in fresh fruits, vegetables, whole grains, nuts, seeds, legumes, seafood, yogurt and olive oil lowers the risks for metabolic syndrome [1].
3) Some studies suggest that moderate red wine intake may protect against the development of metabolic syndrome [2]. However, further supportive evidences are required.
4) Interestingly, in a metanalysis chocolate was found to reduce the risks of coronary artery disease, cardiac deaths, diabetes, and stroke by approximately 30%. The possible explanation for this is the presence of polyphenols in chocolates that increases the concentration of nitric oxide (antioxidants) [3].
Trial supportive data
Meta-analysis on effect of Mediterranean diet on metabolic syndrome [4]
1) Source & year - J Am Coll Cardiol, 2011
2) Study design – Meta-analysis
3) Study question - Effect of a Mediterranean diet on metabolic syndrome and its components.
4) Study Population - {50 original research studies (35 clinical trials, 2 prospective and 13 cross-sectional), with 534,906 participants}
5) Study results -
- Mediterranean diet was associated with reduced risk of metabolic syndrome (log hazard ratio: -0.69, 95% confidence interval [CI]: -1.24 to -1.16)
- Also, statistically significant reduction in waist circumference, triglycerides, systolic and diastolic blood pressure and glucose was found. Additionally, an elevation of HDL cholesterol levels was demonstrated.
PREDIMED: Randomized controlled trial on effect of Mediterranean diet on metabolic syndrome [5]
1) Source & year - Arch Intern Med. 2008
2) Study name - PREDIMED (Prevención con Dieta Mediterránea)
3) Study design – Multicenter, 3-arm randomized controlled trial.
4) Study question – Determine the efficacy of the MedDiet on the primary prevention of cardiovascular disease
5) Study Population – 1224 participant
6) Study period – 1 yr
7) Interventions - quarterly education about the MedDiet plus provision of either 1 L/wk of virgin olive oil (MedDiet + VOO) or 30 g/d of mixed nuts (MedDiet + nuts), and advice on a low-fat diet (control diet).
8) Study results – • 61.4% of participants met criteria for the metabolic syndrome • One-year prevalence was reduced by 6.7%, 13.7%, and 2.0% in the MedDiet + VOO, MedDiet + nuts, and control diet groups, respectively • Med-diet + nuts vs control groups, P = .01; MedDiet + VOO vs control group, P = .18). • After adjustment for sex, age, baseline obesity status, and weight changes
- Odds ratios for reversion of MetS were 1.3 (95% confidence interval, 0.8-2.1) for the MedDiet + VOO
- Odds ratios for reversion of MetS were 1.7 (1.1-2.6) for the MedDiet + nuts group compared with the control diet group.
See also
References
- ↑ Barnes DE (2011). "The mediterranean diet: good for the heart = good for the brain?". Ann Neurol. 69 (2): 226–8. doi:10.1002/ana.22376. PMID 21387364.
- ↑ Liu L, Wang Y, Lam KS, Xu A (2008). "Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications". Endocr Metab Immune Disord Drug Targets. 8 (2): 89–98. PMID 18537695.
- ↑ Buitrago-Lopez A, Sanderson J, Johnson L, Warnakula S, Wood A, Di Angelantonio E; et al. (2011). "Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis". BMJ. 343: d4488. doi:10.1136/bmj.d4488. PMC 3163382. PMID 21875885.
- ↑ Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA, Panagiotakos DB (2011). "The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals". J Am Coll Cardiol. 57 (11): 1299–313. doi:10.1016/j.jacc.2010.09.073. PMID 21392646.
- ↑ Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R; et al. (2008). "Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial". Arch Intern Med. 168 (22): 2449–58. doi:10.1001/archinte.168.22.2449. PMID 19064829.