Mast cell stabilizer: Difference between revisions
Jump to navigation
Jump to search
m Protected "Mast cell stabilizer": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)) |
mNo edit summary |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
'''Mast cell stabilizers''' are [[cromone]] [[medication]]s used to prevent or control certain [[allergy|allergic]] disorders. They block a calcium channel essential for [[mast cell]] [[degranulation]], stabilizing the cell and so prevent the release of [[histamine]]<ref>http://www.mayoclinic.com/health/allergy-medications/AA00037</ref> and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. | '''Mast cell stabilizers''' are [[cromone]] [[medication]]s used to prevent or control certain [[allergy|allergic]] disorders. They block a calcium channel essential for [[mast cell]] [[degranulation]], stabilizing the cell and so prevent the release of [[histamine]]<ref>http://www.mayoclinic.com/health/allergy-medications/AA00037</ref> and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. | ||
| Line 9: | Line 8: | ||
==References== | ==References== | ||
{{reflist|2}} | |||
{{Asthma_and_copd_rx}} | {{Asthma_and_copd_rx}} | ||
{{SIB}} | |||
[[Category:Mast cell stabilizers]] | [[Category:Mast cell stabilizers]] | ||
[[Category:Drug]] | |||
[[Category:Pulmonology]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 04:52, 30 September 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mast cell stabilizers are cromone medications used to prevent or control certain allergic disorders. They block a calcium channel essential for mast cell degranulation, stabilizing the cell and so prevent the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.
As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. Finally in oral form they are used to treat the rare condition of mastocytosis.