Aldosterone antagonist: Difference between revisions
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==Overview== | |||
'''Aldosterone antagonist''' refers to drugs which [[receptor antagonist|antagonise]] the action of [[aldosterone]] at [[mineralocorticoid receptor]]s. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of [[chronic heart failure]]. Spironolactone, the first member of the class, is also used in the management of [[hyperaldosteronism]] (including [[Conn's syndrome]]) and female [[hirsutism]]. | '''Aldosterone antagonist''' refers to drugs which [[receptor antagonist|antagonise]] the action of [[aldosterone]] at [[mineralocorticoid receptor]]s. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of [[chronic heart failure]]. Spironolactone, the first member of the class, is also used in the management of [[hyperaldosteronism]] (including [[Conn's syndrome]]) and female [[hirsutism]]. | ||
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* [[Eplerenone]] | * [[Eplerenone]] | ||
== | ==Related Chapters== | ||
* [[Potassium-sparing diuretic]] | * [[Potassium-sparing diuretic]] | ||
* [[ATC_code_C03#C03DA_Aldosterone_antagonists]] | * [[ATC_code_C03#C03DA_Aldosterone_antagonists]] | ||
== | ==Resources== | ||
* {{MeshName|Aldosterone+Antagonists}} | * {{MeshName|Aldosterone+Antagonists}} | ||
* {{MeshPharmaList|82000451}} | * {{MeshPharmaList|82000451}} | ||
==References== | |||
{{reflist|2}} | |||
{{Hormone antagonists}} | {{Hormone antagonists}} | ||
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[[Category:Steroids]] | [[Category:Steroids]] | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Cardiology]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 12:59, 29 October 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Aldosterone antagonist refers to drugs which antagonise the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome) and female hirsutism.
Mode of action
Aldosterone antagonists are, as the name suggests, receptor antagonists at the mineralocorticoid receptor. Antagonism of these receptors inhibits sodium resorption in the distal tubule of the nephron in the kidneys. This interferes with sodium/potassium exchange, reducing urinary potassium excretion and weakly increasing water excretion (diuresis). [1]
Their adjunctive use in congestive heart failure relates to their additive diuretic effect in combination with other drugs, reducing edema and decreasing the cardiac workload.
Examples
Members of this class in clinical use include:
Related Chapters
Resources
- Aldosterone+Antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)
- Template:MeshPharmaList
References
- ↑ Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006.