Breast cancer bone metastasis: Difference between revisions

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==Overview==
==Overview==
Bone is the most common site of breast cancer recurrence <ref name="pmid17062708">{{cite journal| author=Coleman RE| title=Clinical features of metastatic bone disease and risk of skeletal morbidity. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 20 Pt 2 | pages= 6243s-6249s | pmid=17062708 | doi=10.1158/1078-0432.CCR-06-0931 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17062708  }} </ref>, <ref name="pmid3814476">{{cite journal| author=Coleman RE, Rubens RD| title=The clinical course of bone metastases from breast cancer. | journal=Br J Cancer | year= 1987 | volume= 55 | issue= 1 | pages= 61-6 | pmid=3814476 | doi= | pmc=PMC2001575 | url= }} </ref>. Despite modern cancer therapy, up to two thirds of patients with bone metastasis will subsequently develop an skeletal-related event (sre), defined as any of the following:
Bone is the most common site of breast cancer recurrence <ref name="pmid17062708">{{cite journal| author=Coleman RE| title=Clinical features of metastatic bone disease and risk of skeletal morbidity. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 20 Pt 2 | pages= 6243s-6249s | pmid=17062708 | doi=10.1158/1078-0432.CCR-06-0931 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17062708  }} </ref>, <ref name="pmid3814476">{{cite journal| author=Coleman RE, Rubens RD| title=The clinical course of bone metastases from breast cancer. | journal=Br J Cancer | year= 1987 | volume= 55 | issue= 1 | pages= 61-6 | pmid=3814476 | doi= | pmc=PMC2001575 | url= }} </ref>. A Skeletal-Related event (sre)is defined as any of the following:
*pathologic fracture,  
*pathologic fracture,  
*a requirement for surgical intervention and palliative radiotherapy to bone lesions,
*a requirement for surgical intervention and palliative radiotherapy to bone lesions,
*spinal cord compression
*hypercalcemia of malignancy
*hypercalcemia of malignancy
*spinal cord compression
 
Not only are sres associated with significant morbidity, they also negatively affect survival. Moreover, sres are associated with loss of mobility and social functioning, and reduction in quality of life.
SRE cause major morbidity, decrease survival and reduce quality of life.


==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 22:24, 22 November 2011

Overview

Bone is the most common site of breast cancer recurrence [1], [2]. A Skeletal-Related event (sre)is defined as any of the following:

  • pathologic fracture,
  • a requirement for surgical intervention and palliative radiotherapy to bone lesions,
  • spinal cord compression
  • hypercalcemia of malignancy

SRE cause major morbidity, decrease survival and reduce quality of life.

References

  1. ↑ Coleman RE (2006). "Clinical features of metastatic bone disease and risk of skeletal morbidity". Clin Cancer Res. 12 (20 Pt 2): 6243s–6249s. doi:10.1158/1078-0432.CCR-06-0931. PMID 17062708.
  2. ↑ Coleman RE, Rubens RD (1987). "The clinical course of bone metastases from breast cancer". Br J Cancer. 55 (1): 61–6. PMC 2001575. PMID 3814476.
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