Bivalirudin mechanism of action: Difference between revisions
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Created page with "{{SI}} {{CMG}} ==Overview== ==Mechanism of action== 1) Specific and reversible direct thrombin inhibitor 2) Binds to the catalytic and anionic sites of both circulating and clo..." |
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2) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin. | 2) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin. | ||
3) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII. | 3) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII. | ||
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Revision as of 17:53, 1 December 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mechanism of action
1) Specific and reversible direct thrombin inhibitor
2) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin.
3) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII.