Heparin-induced thrombocytopenia history and symptoms

WikiDoc Resources for Heparin-induced thrombocytopenia history and symptoms
Articles
Most recent articles on Heparin-induced thrombocytopenia history and symptoms Most cited articles on Heparin-induced thrombocytopenia history and symptoms Review articles on Heparin-induced thrombocytopenia history and symptoms Articles on Heparin-induced thrombocytopenia history and symptoms in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Heparin-induced thrombocytopenia history and symptoms Images of Heparin-induced thrombocytopenia history and symptoms Photos of Heparin-induced thrombocytopenia history and symptoms Podcasts & MP3s on Heparin-induced thrombocytopenia history and symptoms Videos on Heparin-induced thrombocytopenia history and symptoms
Evidence Based Medicine
Cochrane Collaboration on Heparin-induced thrombocytopenia history and symptoms Bandolier on Heparin-induced thrombocytopenia history and symptoms TRIP on Heparin-induced thrombocytopenia history and symptoms
Clinical Trials
Ongoing Trials on Heparin-induced thrombocytopenia history and symptoms at Clinical Trials.gov Trial results on Heparin-induced thrombocytopenia history and symptoms Clinical Trials on Heparin-induced thrombocytopenia history and symptoms at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Heparin-induced thrombocytopenia history and symptoms NICE Guidance on Heparin-induced thrombocytopenia history and symptoms NHS PRODIGY Guidance FDA on Heparin-induced thrombocytopenia history and symptoms CDC on Heparin-induced thrombocytopenia history and symptoms
Books
Books on Heparin-induced thrombocytopenia history and symptoms
News
Heparin-induced thrombocytopenia history and symptoms in the news Be alerted to news on Heparin-induced thrombocytopenia history and symptoms News trends on Heparin-induced thrombocytopenia history and symptoms
Commentary
Blogs on Heparin-induced thrombocytopenia history and symptoms
Definitions
Definitions of Heparin-induced thrombocytopenia history and symptoms
Patient Resources / Community
Patient resources on Heparin-induced thrombocytopenia history and symptoms Discussion groups on Heparin-induced thrombocytopenia history and symptoms Patient Handouts on Heparin-induced thrombocytopenia history and symptoms Directions to Hospitals Treating Heparin-induced thrombocytopenia history and symptoms Risk calculators and risk factors for Heparin-induced thrombocytopenia history and symptoms
Healthcare Provider Resources
Symptoms of Heparin-induced thrombocytopenia history and symptoms Causes & Risk Factors for Heparin-induced thrombocytopenia history and symptoms Diagnostic studies for Heparin-induced thrombocytopenia history and symptoms Treatment of Heparin-induced thrombocytopenia history and symptoms
Continuing Medical Education (CME)
CME Programs on Heparin-induced thrombocytopenia history and symptoms
International
Heparin-induced thrombocytopenia history and symptoms en Espanol Heparin-induced thrombocytopenia history and symptoms en Francais
Business
Heparin-induced thrombocytopenia history and symptoms in the Marketplace Patents on Heparin-induced thrombocytopenia history and symptoms
Experimental / Informatics
List of terms related to Heparin-induced thrombocytopenia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Heparin-induced thrombocytopenia is diagnosed when the platelet count falls by > 50% typically after 5-10 days of heparin therapy. Unlike other immune mediated thrombocytopenia (idiopathic thrombocytopenic purpura), the levels of platelet stays > 20,000 microl, thus frank clinical bleeding is less common in HIT when compared to other conditions, where the platelet may fall below 10,000/ microl.

History

• Occurs commonly after 5-10 days of initiation of heparin therapy. Onset of HIT after 2 weeks of heparin therapy is uncommon. Earlier onset of HIT is usually seen in patients who have been previously treated with heparin (1-3 months back) and have circulating HIT antibodies in them. In these patients the median time of platelet fall is less than 12 hours after the start of heparin administration
• Delayed onset HIT is uncommon.
  • Occurs after heparin has been withdrawn (median time of 14 days after heparin withdrawl)
  • High titer platelet-activating antibodies that exhibited increased heparin-dependent as well as heparin-INDEPENDENT platelet activation, perhaps explaining why this complication arose after all heparin should have been cleared from the body.
  • The phenomena is sometimes explained by the fact that unusually high antibody levels react with platelet-associated PF4 bound to non-heparin glycosaminoglycans like chondroitin sulfate and not to heparin