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   MeshID        = D002822 |
   MeshID        = D002822 |
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{{SI}}
{{Choriocarcinoma}}
'''Editor-in-Chief:''' Somal Khan, M.D.
{{CMG}}; {{AOEIC}} Somal Khan, M.D.


==Overview==
==[[Choriocarcinoma overview|Overview]]==
'''Choriocarcinoma''' is a malignant and aggressive [[cancer]] of the [[placenta]]. It is characterized by '''early hematogenous spread''' to the lungs. It belongs to the far end of the spectrum of [[gestational trophoblastic diseases]] (GTD).


==Classification of GTDs==
==[[Choriocarcinoma historical perspective|Historical Perspective]]==
Broadly, gestational trophoblastic diseases can be classified in the following:


1. [[Hydatidiform Mole]]
==[[Choriocarcinoma classification|Classification of GTD]]==
:a. Complete Mole
:b. Partial Mole
2. Invasive Mole<br>


3. Choriocarcinoma
==[[Choriocarcinoma pathophysiology|Pathophysiology]]==


4. Placental site trophoblastic tumor
==[[Choriocarcinoma epidemiology and demographics|Epidemiology and Demographics]]==


== Etiology/Epidemiology ==
==[[Choriocarcinoma risk factors|Risk Factors]]==
It is preceded by:
* [[Hydatidiform mole]] (50% of cases)
* [[Spontaneous abortion]] (20% of cases)
* [[Ectopic pregnancy]] (2% of cases)
* Normal term [[pregnancy]] (20-30% of cases)


==Symptoms/Signs/Labs==
==[[Choriocarcinoma screening|Screening]]==
* increased quantitative [[human chorionic gonadotropin|&beta;-hCG]] levels
* [[vaginal bleeding]]
* [[shortness of breath]]
* [[hemoptysis]] (coughing up blood)
* [[chest pain]]
* [[chest X-ray]] shows multiple infiltrates of various shapes in both lungs
* presents in males as a [[testicular_cancer|testicular neoplasm]]


==Pathology==
==[[Choriocarcinoma causes|Causes]]==  
On [[light microscopy]], there is malignant [[trophoblast]]ic proliferation without hydropic villi.
 
==[[Choriocarcinoma differential diagnosis|Differentiating Choriocarcinoma from other Diseases]]==
 
==[[Choriocarcinoma natural history|Natural History, Complications & Prognosis]]==
 
==Diagnosis==
[[Choriocarcinoma history and symptoms|History and Symptoms]] | [[Choriocarcinoma physical examination|Physical Examination]] | [[Choriocarcinoma laboratory tests|Laboratory Tests]] | [[Choriocarcinoma electrocardiogram|Electrocardiogram]] | [[Choriocarcinoma chest x ray|Chest X Ray]] | [[Choriocarcinoma CT|CT]] | [[Choriocarcinoma MRI|MRI]] | [[Choriocarcinoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Choriocarcinoma other imaging findings|Other Imaging Findings]] | [[Choriocarcinoma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
Choriocarcinoma is one of the tumors that is most sensitive to [[chemotherapy]]. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured however metastatic disease to the kidneys and/or brain is usually fatal. Chemotherapy regimen include EMACO ([[etoposide]], [[methotrexate]], [[actinomycin D]], [[cyclosphosphamide]] and [[oncovin]]). 
[[Choriocarcinoma medical therapy#Chemotherapy|Chemotherapy]] | [[Choriocarcinoma surgery#Hysterectomy|Hysterectomy]] | [[Choriocarcinoma primary prevention|Primary Prevention]] | [[Choriocarcinoma secondary prevention|Secondary Prevention]]


[[Hysterectomy]] (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.


{{Soft tissue tumors and sarcomas}}
{{Soft tissue tumors and sarcomas}}
{{SIB}}


[[Category:Disease]]
[[Category:Gynecology]]
[[Category:Gynecology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Oncology]]


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Revision as of 13:42, 14 January 2012

For patient information, click here

Choriocarcinoma
ICD-10 C58
ICD-9 181
ICD-O: 9100-9101
DiseasesDB 2602
MeSH D002822

Template:Choriocarcinoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Somal Khan, M.D.

Overview

Historical Perspective

Classification of GTD

Pathophysiology

Epidemiology and Demographics

Risk Factors

Screening

Causes

Differentiating Choriocarcinoma from other Diseases

Natural History, Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Tests | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Chemotherapy | Hysterectomy | Primary Prevention | Secondary Prevention



Template:WikiDoc Sources

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