Langerhans cell histiocytosis laboratory tests: Difference between revisions
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<br />Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | <br />Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | ||
<br />Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes. | <br />Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes. | ||
Assessment of [[endocrine]] function and bonemarrow biopsy are also performed when indicated. | |||
==References== | ==References== | ||
Revision as of 02:11, 19 January 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Lab Tests
Diagnosis of LCH is confirmed histologically by tissue biopsy.
Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.
Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
Assessment of endocrine function and bonemarrow biopsy are also performed when indicated.