Burkitt's lymphoma: Difference between revisions

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{{Infobox_Disease |
{{Infobox_Disease |
   Name          = Burkitt's lymphoma |
   Name          = Burkitt's lymphoma |
   Image          = Burkitt lymphoma, touch prep, Wright stain.jpg |
   Image          = Burkitt lymphoma, touch prep, Wright stain.jpg |
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{{Burkitt's lymphoma}}
{{Burkitt's lymphoma}}
{{CMG}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
{{CMG}}
==[[Burkitt's lymphoma overview|Overview]]==
==Overview==
 
==[[Burkitt's lymphoma pathophysiology|Pathophysiology]]==
 
==[[Burkitt's lymphoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Burkitt's lymphoma risk factors|Risk Factors]]==
 
==[[Burkitt's lymphoma screening|Screening]]==
 
==[[Burkitt's lymphoma natural history|Natural History, Complications and Prognosis]]==
 
==[[Burkitt's lymphoma classification|Classification]]==
 
==[[Burkitt's lymphoma causes|Causes]]==
 
==[[Burkitt's lymphoma differential diagnosis|Differentiating Burkitt's lymphoma from other Disorders]]==


==Microscopy==
== Diagnosis ==  
Consists of undifferentiated, small, noncleaved cells in broad sheets of tumor cells.
Burkitt's lymphoma demonstrates starry sky appearance due to the macrophage ingestion of tumor cells.


==Malignant B cell characteristics==
:[[Burkitt's lymphoma history and symptoms| History and Symptoms]] | [[Burkitt's lymphoma physical examination | Physical Examination]] | [[Burkitt's lymphoma staging | Staging]] | [[Burkitt's lymphoma laboratory tests | Lab Studies]] | [[Burkitt's lymphoma electrocardiogram|Electrocardiogram]] | [[Burkitt's lymphoma chest x ray|Chest X Ray]] |  [[Burkitt's lymphoma MRI|MRI]] | [[Burkitt's lymphoma CT|CT]] | [[Burkitt's lymphoma echocardiography|Echocardiography]] | [[Burkitt's lymphoma other diagnostic studies|Other Diagnostic Studies]]
Malignant B cells have identical DNA recombinations of the V(D)J region of the Immunoglobin genes. This means that no increase in specificity of Antibody molecules is occurring in the malignant cells. These malignant cells are thus clonal populations and can be assayed for by using DNA probes specific for the regions where recombination is expected. Normal DNA will be characterized by two high concentration of identical germ line DNA V(D)J regions and endless, likely undetectable, non-germline Ig V(D)J DNA. Lymphoma cells have an additional high concentration of V(D)J DNA that is unlike the germline, indicating clonal populations of B Cells that are not undifferentiated B Cells (Germline DNA cells). Assays typically use the process of Electrophoresis and southern blot analysis to determine the existence of these characteristics.


==Treatment==
==Treatment==


:'''Medical:''' [[Burkitt's lymphoma medical therapy| Medical Therapy]]
:'''Surgical:''' [[Burkitt's lymphoma surgery| Surgery]]


==Case Studies==
'''


{{Chromosomal abnormalities}}
{{Chromosomal abnormalities}}

Revision as of 15:34, 20 January 2012

Burkitt's lymphoma
Burkitt lymphoma, touch prep, Wright stain
ICD-10 C83.7
ICD-9 200.2
ICD-O: 9687/3
OMIM 113970
DiseasesDB 1784
MeSH D002051

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] For patient information click here

Overview

Pathophysiology

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Classification

Causes

Differentiating Burkitt's lymphoma from other Disorders

Diagnosis

History and Symptoms | Physical Examination | Staging | Lab Studies | Electrocardiogram | Chest X Ray | MRI | CT | Echocardiography | Other Diagnostic Studies

Treatment

Medical: Medical Therapy
Surgical: Surgery

Case Studies

Template:Chromosomal abnormalities

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