Chronic myelogenous leukemia overview: Difference between revisions
Created page with "{{Chronic myelogenous leukemia}} {{CMG}} ==Overview== ==References== {{reflist|2}} Category:Disease Category:Types of cancer Category:Hematology [[Category:Onc..." |
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==Overview== | ==Overview== | ||
'''Chronic myelogenous leukemia''' ('''CML''') is a form of [[leukemia]] characterized by the increased and unregulated growth of predominantly [[myeloid]] cells in the [[bone marrow]] and the accumulation of these cells in the blood. CML is a clonal bone marrow [[stem cell]] disorder in which proliferation of mature [[granulocyte]]s ([[neutrophil]]s, [[eosinophil]]s, and [[basophil]]s) and their precursors is the main finding. It is a type of [[myeloproliferative disease]] associated with a characteristic [[chromosomal translocation]] called the [[Philadelphia chromosome]]. Historically, it has been treated with [[chemotherapy]], [[interferon]] and [[bone marrow transplantation]], although [[targeted therapy|targeted therapies]] introduced at the beginning of the 21st century have radically changed the management of CML. | |||
==References== | ==References== | ||
Revision as of 15:55, 20 January 2012
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Chronic myelogenous leukemia Microchapters |
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Differentiating Chronic myelogenous leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Chronic myelogenous leukemia overview On the Web |
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American Roentgen Ray Society Images of Chronic myelogenous leukemia overview |
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Directions to Hospitals Treating Chronic myelogenous leukemia |
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Risk calculators and risk factors for Chronic myelogenous leukemia overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chronic myelogenous leukemia (CML) is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Historically, it has been treated with chemotherapy, interferon and bone marrow transplantation, although targeted therapies introduced at the beginning of the 21st century have radically changed the management of CML.