Pleomorphic adenoma: Difference between revisions

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==Treatment==
==Treatment==
==[[Pleomorphic adenoma surgery|Surgery]]==
==[[Pleomorphic adenoma surgery|Surgery]]==
Overall, the mainstay of the treatment for salivary gland tumor is surgical resection. Needle biopsy is highly recommended prior to surgery to confirm the diagnosis. More detailed surgical technique and the support for additional [[adjuvant]] radiotherapy depends on whether the tumor is malignant or benign.  Generally, benign tumors of the parotid gland are treated with superficial or total parotidectomy with the latter being the more commonly practiced due to high incidence of recurrence<ref>{{cite journal |author=Stennert E, Guntinas-Lichius O, Klussmann JP, Arnold G |title=Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases |journal=Laryngoscope |volume=111 |issue=12 |pages=2195–200 |year=2001 |month=Dec |pmid=11802025 |doi= 10.1097/00005537-200112000-00024|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0023-852X&volume=111&issue=12&spage=2195}}</ref>.  The [[facial nerve]] should be preserved whenever possible. The benign tumors of the [[submandibular gland]] is treated by simple excision with preservation of mandibular branch of the [[trigeminal nerve]], the [[hypoglossal nerve]], and the [[lingual nerve]]<ref>{{cite journal |author=Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B |title=Recurrent pleomorphic adenoma of the parotid gland |journal=Otolaryngol Head Neck Surg |volume=133 |issue=3 |pages=319–22 |year=2005 |month=Sep |pmid=16143173 |doi=10.1016/j.otohns.2005.04.008 |url=}}</ref>. Similarly, other benign tumors of minor salivary glands are treated similarly.  Malignant salivary tumors usually require wide local resection of the primary tumor. However, if complete resection cannot be achieved, adjuvant radiotherapy should be added to improve local control<ref>{{cite journal |author=Ganly I, Patel SG, Coleman M, Ghossein R, Carlson D, Shah JP |title=Malignant minor salivary gland tumors of the larynx |journal=Arch Otolaryngol Head Neck Surg. |volume=132 |issue=7 |pages=767–70 |year=2006 |month=Jul |pmid=16847187 |doi=10.1001/archotol.132.7.767 |url=}}</ref><ref>{{cite journal |author=Terhaard CH, Lubsen H, Rasch CR, ''et al'' |title=The role of radiotherapy in the treatment of malignant salivary gland tumors |journal=Int J Radiat Oncol Biol Phys |volume=61 |issue=1 |pages=103–11 |year=2005 |month=Jan |pmid=15629600 |doi=10.1016/j.ijrobp.2004.03.018 |url=}}</ref>. This surgical treatment has many sequellae such as cranial nerve damage, [[Frey's syndrome]] , cosmetic problems, etc.


==References==
==References==

Revision as of 15:30, 21 January 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Cafer Zorkun M.D., PhD.

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The diagnosis of salivary gland tumors utilize both histopathological sampling and radiographic studies. Histopathological sampling procedures include fine needle aspiration (FNA) and core needle biopsy (bigger needle comparing to FNA). Both of these procedures can be done in an outpatient setting. Diagnostic imaging techniques for salivary gland tumors include ultrasound, computer tomography (CT) and magnetic resonance imaging (MRI). Fine needle aspiration biopsy (FNA), operated in experienced hands, can determine whether the tumor is malignant in nature with sensitivity around 90%[1][2]. FNA can also distinguish primary salivary tumor from metastatic disease. Core needle biopsy can also be done in outpatient setting. It is more invasive but is more accurate compared to FNA with diagnostic accuracy greater than 97%[3]. Furthermore, core needle biopsy allows more accurate histological typing of the tumor. In terms of imaging studies, ultrasound can determine and characterize superficial parotid tumors. Certain types of salivary gland tumors have certain sonographic characteristics on ultrasound[4]. Ultrasound is also frequently used to guide FNA or core needle biopsy. CT allows direct, bilateral visualization of the salivary gland tumor and provides information about overall dimension and tissue invasion. CT is excellent for demonstrating bony invasion. MRI provides superior soft tissue delineation such as perineural invasion when compared to CT only[5].

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References

  1. ↑ Cohen EG, Patel SG, Lin O; et al. (2004). "Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population". Arch Otolaryngol Head Neck Surg. 130 (6): 773–8. doi:10.1001/archotol.130.6.773. PMID 15210562. Unknown parameter |month= ignored (help)
  2. ↑ Batsakis JG, Sneige N, el-Naggar AK (1992). "Fine-needle aspiration of salivary glands: its utility and tissue effects". Ann Otol Rhinol Laryngol. 101 (2 Pt 1): 185–8. PMID 1739267. Unknown parameter |month= ignored (help)
  3. ↑ Wan YL, Chan SC, Chen YL; et al. (2004). "Ultrasonography-guided core-needle biopsy of parotid gland masses". AJNR Am J Neuroradiol. 25 (9): 1608–12. PMID 15502149. Unknown parameter |month= ignored (help)
  4. ↑ Białek EJ, Jakubowski W, Karpińska G (2003). "Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress". Arch Otolaryngol Head Neck Surg. 129 (9): 929–33. doi:10.1001/archotol.129.9.929. PMID 12975263. Unknown parameter |month= ignored (help)
  5. ↑ Koyuncu M, Seşen T, Akan H; et al. (2003). "Comparison of computed tomography and magnetic resonance imaging in the diagnosis of parotid tumors". Otolaryngol Head Neck Surg. 129 (6): 726–32. doi:10.1016/j.otohns.2003.07.009. PMID 14663442. Unknown parameter |month= ignored (help)

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