Granulomatous amoebic encephalitis: Difference between revisions
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==[[Granulomatous amoebic encephalitis CT|CT]]== | ==[[Granulomatous amoebic encephalitis CT|CT]]== | ||
==Appearance on Biopsy== | ==Appearance on Biopsy== | ||
Revision as of 16:51, 3 February 2012
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Granulomatous amoebic encephalitis Microchapters |
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Differentiating Granulomatous amoebic encephalitis from other Diseases |
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Diagnosis |
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Granulomatous amoebic encephalitis On the Web |
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Risk calculators and risk factors for Granulomatous amoebic encephalitis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Diagnosis
History & Symptoms
CT
Appearance on Biopsy
A brain biopsy will reveal the presence of infection by pathogenic amoebas. In GAE, these present as general inflammation and sparse granules. On microscopic examination, infiltrates of amoebic cysts and/or trophozoites will be visible.
Cerebrospinal Fluid
The CSF demonstrates a lymphocytic pleocytosis, with mildly elevated protein and normal glucose, but diagnostic organisms are not readily identified. Lumbar puncture is contraindicated if there are signs and symptoms of an increase in intracranial pressure.
Treatment
Medical Therapy
GAE can, in general, must be treated by killing the pathogenic amoebas which cause it. Even with treatment, the condition is often fatal, and there are very few recorded survivors, almost all of whom suffered permanent neurocognitive deficits. Several drugs have been shown to be effective against GAE-causing organisms in vitro.[1]
References
External links
- Intalapaporn P, Suankratay C, Shuangshoti S, Phantumchinda K, Keelawat S, Wilde H (2004). "Balamuthia mandrillaris meningoencephalitis: the first case in southeast Asia". Am. J. Trop. Med. Hyg. 70 (6): 666–9. PMID 15211011.