Meningococcemia medical therapy: Difference between revisions
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(Created page with "{{Meningococcemia}} {{CMG}}; '''Associate Editor(s)-In-Chief:''' {{CZ}} ==Overview== ==References== {{reflist|2}} {{WikiDoc Help Menu}} {{WikiDoc Sources}} [[Category:Dise...") |
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==Overview== | ==Overview== | ||
==Treatment== | |||
===Acute Pharmacotherapies === | |||
* [[Cephalosporin]] CSF penetration: [[cefuroxime]] 11-14 %; [[ceftriaxone]] 1.5-7%, [[cefotaxime]] 4-54%, and [[ceftazidime]] 14%. | |||
* [[Ceftriaxone]] CSF half life approximately 5 hours. | |||
* Potential antibiotics include [[cephalosporin]]s, [[penicillin]], and [[chloramphenicol]]. | |||
* Therapy may be as brief as 10 to 14 days in fully sensitive organisms. | |||
* Steroid use particularly in [[purpura fulminans]] and [[adrenal hemorrhage]] ([[Waterhouse-Friderichsen syndrome]]) is controversial. | |||
===Prophylaxis=== | |||
* [[Rifampin]] 600 mg PO q12h x 4 doses total or alternatively [[ciprofloxacin]] 500 mg PO x 1 in patients over 18 who cannot tolerate [[rifampin]] | |||
==References== | ==References== | ||
Revision as of 21:19, 8 February 2012
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Meningococcemia Microchapters |
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Risk calculators and risk factors for Meningococcemia medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Treatment
Acute Pharmacotherapies
- Cephalosporin CSF penetration: cefuroxime 11-14 %; ceftriaxone 1.5-7%, cefotaxime 4-54%, and ceftazidime 14%.
- Ceftriaxone CSF half life approximately 5 hours.
- Potential antibiotics include cephalosporins, penicillin, and chloramphenicol.
- Therapy may be as brief as 10 to 14 days in fully sensitive organisms.
- Steroid use particularly in purpura fulminans and adrenal hemorrhage (Waterhouse-Friderichsen syndrome) is controversial.
Prophylaxis
- Rifampin 600 mg PO q12h x 4 doses total or alternatively ciprofloxacin 500 mg PO x 1 in patients over 18 who cannot tolerate rifampin