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==Natural history==
==Natural history==
Rubella was first described in the mid-eighteenth century. [[Friedrich Hoffmann]] made the first clinical description of rubella in 1740,<ref name=Ackerknecht1982>{{cite book |author=Ackerknecht, Erwin Heinz |title=A short history of medicine |publisher=Johns Hopkins University Press |location=Baltimore |year=1982 |pages=129 |isbn=0-8018-2726-4}}</ref> which was confirmed by de Bergen in 1752 and Orlow in 1758.<ref name="pmid18109609">{{cite journal
|author=Wesselhoeft C
|title=Rubella and congenital deformities
|journal=N. Engl. J. Med.
|volume=240
|issue=7
|pages=258–61
|year=1949
|pmid=18109609
|doi=
}}</ref>
In 1814, George de Maton first suggested that it be considered a disease distinct from both measles and scarlet fever. All these physicians were German, and the disease was known  as Rötheln (from the German name ''Röteln''), hence the common name of "German measles". <ref>Best, J.M., Cooray, S.,  Banatvala J.E. '''Rubella''' in ''Topley and Wilson's Microbiology and Microbial Infections'', Vol. 2, Virology, Chapter 45, p.960-92, ISBN 0 340 88562 9, 2005 </ref> Henry Veale, an English Royal Artillery surgeon, described an outbreak in India. He coined the name "rubella" (from the Latin, meaning "little red") in 1866.<ref name=Ackerknecht1982/><ref name=Lee2000>{{cite journal |author=Lee JY, Bowden DS |title=Rubella virus replication and links to teratogenicity |journal=Clin. Microbiol. Rev. |volume=13 |issue=4 |pages=571-87 |year=2000 |pmid=11023958 |url=http://cmr.asm.org/cgi/content/full/13/4/571}}</ref><ref name=cdc>{{cite book
| author = Atkinson W, Hamborsky J, McIntyre L, Wolfe S, eds.
| year = 2007
| url = http://www.cdc.gov/vaccines/pubs/pinkbook/pink-chapters.htm
| title = Epidemiology and Prevention of Vaccine-Preventable Diseases. 10th ed.
| chapter = Chapter 12. Rubella
| chapterURL = http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/rubella.pdf
| publisher = Centers for Disease Control and Prevention
| accessdate = 2007-07-03
}}</ref><ref name=MoHNZ>{{cite book
| year = 2006
| month = April
| title = Immunisation Handbook 2006
| publisher = Ministry of Health, Wellington, NZ.
| url = http://www.moh.govt.nz/moh.nsf/indexmh/immunisation-handbook-2006
| chapter = Chapter 11 - Rubella
| chapterURL = http://www.moh.govt.nz/moh.nsf/pagesmh/4617/$File/2006-11rubella.pdf
| isbn=0-478-29926-5
| accessdate = 2007-07-03
}}</ref>
It was formally recognised as an individual entity in 1881, at the International Congress of Medicine in London.<ref>Smith, J. L. Contributions to the study of Rötheln. Trans. Int. Med. Congr. Phil. '''4''',14. 1881</ref> In 1914, Alfred Fabian Hess theorised that rubella was caused by a virus, based on work with monkeys.<ref name=whonamedit>{{cite journal
| first = Alfred Fabian
| last = Hess
| year = 1914
| title = German measles (rubella): an experimental study
| journal = The Archives of Internal Medicine
| location = Chicago
| volume = 13
| pages = 913-916
}} as cited by {{cite web
| first = Ole Daniel
| last = Enersen
| url = http://www.whonamedit.com/doctor.cfm/2283.html
| title = Alfred Fabian Hess
| publisher = WhoNamedIt
| accessdate = 2007-07-03
}}</ref> In 1938, Hiro and Tosaka confirmed this by passing the disease to children using filtered nasal washings from acute cases.<ref name=cdc/>
In 1940, there was a widespread epidemic of rubella in Australia. Subsequently, ophthalmologist Norman McAllister Gregg found 78 cases of congenital cataracts in infants and 68 of them were born to mothers who had caught rubella in early pregnancy.<ref name=Lee2000/><ref name=cdc/> Gregg published an account, ''Congenital Cataract Following German Measles in the Mother'', in 1941. He described a variety of problems now know as [[congenital rubella syndrome]] (CRS) and noticed that the earlier the mother was infected, the worse the damage was. The virus was isolated in tissue culture in 1962 by two separate groups led by physicians Parkman and Weller.<ref name=MoHNZ/><ref name=Lee2000/>
There was a pandemic of rubella between 1962 and 1965, starting in Europe and spreading to the United States.<ref name=MoHNZ/> In the years 1964-65, the United States had an estimated 12.5 million rubella cases. This led to 11,000 miscarriages or therapeutic abortions and 20,000 cases of congenital rubella syndrome. Of these, 2,100 died as neonates, 12,000 were deaf, 3,580 were blind and 1,800 were mentally retarded. In New York alone, CRS affected 1% of all births <ref> J.B. Hanshaw, J.A. Dudgeon, and W.C. Marshall. Viral diseases of the fetus and newborn. W.B. Saunders Co., Philadelphia, 1985 </ref>
In 1969 a live attenuated virus vaccine was licensed.<ref name=cdc/> In the early 1970s, a triple vaccine containing attenuated measles, mumps and rubella (MMR) viruses was introduced.<ref name=MoHNZ/>


==Complications==
==Complications==

Revision as of 14:57, 9 February 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Natural history

Rubella was first described in the mid-eighteenth century. Friedrich Hoffmann made the first clinical description of rubella in 1740,[1] which was confirmed by de Bergen in 1752 and Orlow in 1758.[2]

In 1814, George de Maton first suggested that it be considered a disease distinct from both measles and scarlet fever. All these physicians were German, and the disease was known as Rötheln (from the German name Röteln), hence the common name of "German measles". [3] Henry Veale, an English Royal Artillery surgeon, described an outbreak in India. He coined the name "rubella" (from the Latin, meaning "little red") in 1866.[1][4][5][6]

It was formally recognised as an individual entity in 1881, at the International Congress of Medicine in London.[7] In 1914, Alfred Fabian Hess theorised that rubella was caused by a virus, based on work with monkeys.[8] In 1938, Hiro and Tosaka confirmed this by passing the disease to children using filtered nasal washings from acute cases.[5]

In 1940, there was a widespread epidemic of rubella in Australia. Subsequently, ophthalmologist Norman McAllister Gregg found 78 cases of congenital cataracts in infants and 68 of them were born to mothers who had caught rubella in early pregnancy.[4][5] Gregg published an account, Congenital Cataract Following German Measles in the Mother, in 1941. He described a variety of problems now know as congenital rubella syndrome (CRS) and noticed that the earlier the mother was infected, the worse the damage was. The virus was isolated in tissue culture in 1962 by two separate groups led by physicians Parkman and Weller.[6][4]

There was a pandemic of rubella between 1962 and 1965, starting in Europe and spreading to the United States.[6] In the years 1964-65, the United States had an estimated 12.5 million rubella cases. This led to 11,000 miscarriages or therapeutic abortions and 20,000 cases of congenital rubella syndrome. Of these, 2,100 died as neonates, 12,000 were deaf, 3,580 were blind and 1,800 were mentally retarded. In New York alone, CRS affected 1% of all births [9]

In 1969 a live attenuated virus vaccine was licensed.[5] In the early 1970s, a triple vaccine containing attenuated measles, mumps and rubella (MMR) viruses was introduced.[6]

Complications

Prognosis

Rubella infection of children and adults is usually mild, self-limiting and often asymptomatic. The prognosis in children born with CRS is poor.[10]

References

  1. 1.0 1.1 Ackerknecht, Erwin Heinz (1982). A short history of medicine. Baltimore: Johns Hopkins University Press. p. 129. ISBN 0-8018-2726-4.
  2. Wesselhoeft C (1949). "Rubella and congenital deformities". N. Engl. J. Med. 240 (7): 258–61. PMID 18109609.
  3. Best, J.M., Cooray, S., Banatvala J.E. Rubella in Topley and Wilson's Microbiology and Microbial Infections, Vol. 2, Virology, Chapter 45, p.960-92, ISBN 0 340 88562 9, 2005
  4. 4.0 4.1 4.2 Lee JY, Bowden DS (2000). "Rubella virus replication and links to teratogenicity". Clin. Microbiol. Rev. 13 (4): 571–87. PMID 11023958.
  5. 5.0 5.1 5.2 5.3 Atkinson W, Hamborsky J, McIntyre L, Wolfe S, eds. (2007). "Chapter 12. Rubella". Epidemiology and Prevention of Vaccine-Preventable Diseases. 10th ed. Centers for Disease Control and Prevention. Retrieved 2007-07-03. Unknown parameter |chapterURL= ignored (|chapterurl= suggested) (help)
  6. 6.0 6.1 6.2 6.3 "Chapter 11 - Rubella". Immunisation Handbook 2006. Ministry of Health, Wellington, NZ. 2006. ISBN 0-478-29926-5. Retrieved 2007-07-03. Unknown parameter |month= ignored (help); Unknown parameter |chapterURL= ignored (|chapterurl= suggested) (help)
  7. Smith, J. L. Contributions to the study of Rötheln. Trans. Int. Med. Congr. Phil. 4,14. 1881
  8. Hess, Alfred Fabian (1914). "German measles (rubella): an experimental study". The Archives of Internal Medicine. Chicago. 13: 913–916. as cited by Enersen, Ole Daniel. "Alfred Fabian Hess". WhoNamedIt. Retrieved 2007-07-03.
  9. J.B. Hanshaw, J.A. Dudgeon, and W.C. Marshall. Viral diseases of the fetus and newborn. W.B. Saunders Co., Philadelphia, 1985
  10. Freij BJ, South MA, Sever JL (1988). "Maternal rubella and the congenital rubella syndrome". Clin Perinatol. 15 (2): 247–57. PMID 3288422.