Hepatitis D historical perspective: Difference between revisions
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{{ | ==Historical Perspective== | ||
Hepatitis D virus was first reported in the mid-1977, by an italian researcher, Mario Rizzetto, <ref>Manuale di Gastroenterologia Unigastro pag. 260 </ref> as a nuclear antigen in patients infected with HBV who had severe liver disease <ref>{{cite journal|last=Rizzetto|first=M|coauthors=Canese MG, Arico S, Criello O, Trepo C, Bonino F, Verme G|title=Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers|journal=Gut|year=1997|volume=18|issue=12|pages=997–1003|pmid=75123|pmc=1411847|doi=10.1136/gut.18.12.997}}</ref> This nuclear antigen was then thought to be a hepatitis B antigen and was called the delta antigen. Subsequent experiments in chimpanzees showed that the hepatitis delta antigen (HDAg) was a structural part of a pathogen that required HBV infection to replicate<ref>{{cite journal|last=Rizzetto|first=M|coauthors=Canese, MG, Purcell, RH, London, WT, Sly, LD, Gerin, JL|title=Experimental HBV and delta infections of chimpanzees: occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen|journal=Hepatology (Baltimore, Md.)|date=1981 Nov-Dec|year=1981|volume=1|issue=6|pages=567–74|pmid=7030907|doi=10.1002/hep.1840010602}}</ref> The entire virus was cloned and sequenced in 1986, and obtained its own genus deltavirus <ref>{{cite journal|last=Wang|first=KS|coauthors=Choo, QL, Weiner, AJ, Ou, JH, Najarian, RC, Thayer, RM, Mullenbach, GT, Denniston, KJ, Gerin, JL, Houghton, M|title=Structure, sequence and expression of the hepatitis delta (delta) viral genome|journal=Nature|date=1986 Oct 9-15|year=1986|volume=323|issue=6088|pages=508–14|pmid=3762705|doi=10.1038/323508a0}}</ref><ref>{{cite journal|last=Fauquet|first=CM|coauthors=Mayo MA, Maniloff J, Desselberger U, Ball LA|title=Deltavirus|journal=Eight Report of the International Committee on Taxonomy of Viruses. London|year=2005|pages=735–8}}</ref> | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 14:25, 14 March 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
Hepatitis D virus was first reported in the mid-1977, by an italian researcher, Mario Rizzetto, [1] as a nuclear antigen in patients infected with HBV who had severe liver disease [2] This nuclear antigen was then thought to be a hepatitis B antigen and was called the delta antigen. Subsequent experiments in chimpanzees showed that the hepatitis delta antigen (HDAg) was a structural part of a pathogen that required HBV infection to replicate[3] The entire virus was cloned and sequenced in 1986, and obtained its own genus deltavirus [4][5]
References
- ↑ Manuale di Gastroenterologia Unigastro pag. 260
- ↑ Rizzetto, M (1997). "Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers". Gut. 18 (12): 997–1003. doi:10.1136/gut.18.12.997. PMC 1411847. PMID 75123. Unknown parameter
|coauthors=ignored (help) - ↑ Rizzetto, M (1981 Nov-Dec). "Experimental HBV and delta infections of chimpanzees: occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen". Hepatology (Baltimore, Md.). 1 (6): 567–74. doi:10.1002/hep.1840010602. PMID 7030907. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help) - ↑ Wang, KS (1986 Oct 9-15). "Structure, sequence and expression of the hepatitis delta (delta) viral genome". Nature. 323 (6088): 508–14. doi:10.1038/323508a0. PMID 3762705. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help) - ↑ Fauquet, CM (2005). "Deltavirus". Eight Report of the International Committee on Taxonomy of Viruses. London: 735–8. Unknown parameter
|coauthors=ignored (help)