Aortic sclerosis pathophysiology: Difference between revisions
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{{Aortic sclerosis}} | {{Aortic sclerosis}} | ||
{{CMG}} | {{CMG}}; {{AOEIC}} {{LG}} | ||
==Overview== | ==Overview== | ||
Microscopic changes reveal lipoprotein accumulation, cellular infiltration and extracellular matrix formation that cause progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref> | Microscopic changes reveal lipoprotein accumulation, macrophage and T-cellular infiltration, basement membrane disruption and extracellular matrix formation that cause progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref> | ||
==Pathophysiology== | |||
*Otto et al,<ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref> demonstrated the following histological characteristics observed in patients with [[aortic sclerosis]]: | |||
:#Subendothelial thickening on the aortic side of the leaflet, between the basement membrane and elastic lamina, | |||
:#Presence of large amounts of intracellular and extracellular neutral lipids and fine, stippled mineralization, and | |||
:#Disruption of the basement membrane overlying the lesion. | |||
:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation. | |||
==References== | ==References== | ||
Revision as of 16:29, 11 April 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]
Overview
Microscopic changes reveal lipoprotein accumulation, macrophage and T-cellular infiltration, basement membrane disruption and extracellular matrix formation that cause progressive thickening of the aortic valve.[1][2]
Pathophysiology
- Otto et al,[2] demonstrated the following histological characteristics observed in patients with aortic sclerosis:
- Subendothelial thickening on the aortic side of the leaflet, between the basement membrane and elastic lamina,
- Presence of large amounts of intracellular and extracellular neutral lipids and fine, stippled mineralization, and
- Disruption of the basement membrane overlying the lesion.
- Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation.
References
- ↑ Freeman RV, Otto CM (2005). "Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies". Circulation. 111 (24): 3316–26. doi:10.1161/CIRCULATIONAHA.104.486738. PMID 15967862. Retrieved 2012-04-10. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD (1994). "Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies". Circulation. 90 (2): 844–53. PMID 7519131. Retrieved 2012-04-11. Unknown parameter
|month=ignored (help)