Lingual thyroid: Difference between revisions
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{{CMG}} | {{CMG}}; '''Associate Editor-in-Chief:''' [[User:AwniShahait|Awni D. Shahait, M.D.]], The University of Jordan | ||
'''''Synonyms and keywords:''''' LT | '''''Synonyms and keywords:''''' LT | ||
Revision as of 11:11, 15 April 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-in-Chief: Awni D. Shahait, M.D., The University of Jordan
Synonyms and keywords: LT
Overview
Lingual Thyroid (LT) is a rare developmental thyroid anomaly in which the thyroid gland is located in the medial line at the base of the tongue.
Demographics and Epidemiology
Incidence
The incidence is 1 in 100,000. This condition represents 90% of all cases of ectopic thyroid.[1]
Sex
Females are affected more frequently.
Age
There is no age predisposition.
Pathophysiology
Although the pathogenesis of lingual thyroid is not fully understood, it has been speculated to be due to failure of migration of thyroid tissue along the path from ventral floor of the pharynx to its normal location and sequestration within the tongue substance leads to the development of lingual thyroid. [2]
Diagnosis
Symptoms
Infants and Children
The abnormality may be identified during routine screening.
Adolescents
Adolescents may present with dysphagia or symptoms of oropharyngeal obstruction. As a response to the increased metabolic demands for thyroid hormone during puberty, hypertrophy of the gland may be seen.
Conditions of Metabolic Stress
A similar response is also encountered during other metabolic stress conditions like pregnancy, infections, trauma, menopause. [3]
Physical Examination
LT usually presents itself as a midline, nodular mass at the base of the tongue. The surface of the lesion is usually smooth and vascularity can be seen.
Imaging
A scintigraphic scan is the imaging modality of choice. It detects the ectopic thyroid tissue within the lingual thyroid, and also confirms the presence of a functioning thyroid gland, which is reported to be absent in 70% of LT cases.
Laboratory Findings
It’s reported that up to 70% of patients with lingual thyroid have hypothyroidsm and 10% suffer from cretinism.
Treatment
The standard treatment of lingual thyroid varies. Surgical treatment is preferred when there are symptoms like dysphagia or dyspnoea, and also complications such as ulceration, bleeding or rapidly growing mass, suggesting malignant transformation. In patient with obstructive symptom, Iodine131 ablation of ectopic thyroid tissue has been proven successful and may be advantageous than syrgery. In patient lacking thyroid tissue in the neck, the lingual thyroid can be excised and autotransplanted to the muscles of the neck. Various surgical approaches have been recommended. Transoral approach has been reported to be the most frequently used one. Another approach is lateral pharyngotomy which is useful only in the treatment of lesions located in the posterior wall or lateral walls of hypopharynx. It provides a wide exposure compared to transoral approach. Another approach is transhyoid which is more advantageous than the other two approaches in that it provides wider and a direct exposition through the midline.
References
- ↑ Douglas PS, Baker AW (1994). "Lingual thyroid". Br J Oral Maxillofac Surg. 32 (2): 123–4. PMID 8199145. Unknown parameter
|month=ignored (help) - ↑ Ueda D, Yoto Y, Sato T (1998). "Ultrasonic assessment of the lingual thyroid gland in children". Pediatr Radiol. 28 (2): 126–8. PMID 9472062. Unknown parameter
|month=ignored (help) - ↑ Williams JD, Sclafani AP, Slupchinskij O, Douge C (1996). "Evaluation and management of the lingual thyroid gland". Ann. Otol. Rhinol. Laryngol. 105 (4): 312–6. PMID 8604896. Unknown parameter
|month=ignored (help)