Bumps on skin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S.[2]

Complete Differential Diagnosis of the Causes of Bumps on skin

Common Causes

• Acne Vulgaris

• Actinic Keratosis

• Allergic contact dermatitis

• Basal Cell Carcinoma

• Boil

• Dermoid cyst

• Enlarged Lymph Nodes

• Erythema Nodosum
• Folliculitis

• Fungal infections

• Lipoma

• Malignant melanoma

• Moles

• Molluscum Contagiosum

• Pyoderma gangrenosum

• Pyogenic granuloma

• Rash

• Scabies

• Squamous Cell Carcinoma

Causes by Organ System

Cardiovascular	No underlying causes
Chemical / poisoning	No underlying causes
Dermatologic	Cherry angioma, Acne Vulgaris, Actinic Keratosis, Allergic contact dermatitis, Atopic dermatitis , Acrospiroma, Basal Cell Carcinoma, Campbell de Morgan spots, Cleft upper lip, median -- cutaneous polyps, Eczema, Erythema elevatum diutinum, Erythema Nodosum, Febrile Ulceronecrotic Mucha-Habermann disease, Follicular hamartoma -- alopecia -- cystic fibrosis, Folliculitis, Ganglion, Granuloma Annulare, Hashimoto-Pritzker syndrome, Impetigo, Intradermal Cyst, Keratosis Pilaris, Moles, Papular mucinosis, Rosacea, Scleromyxedema, Sebaceous (Epidermoid) Cysts, Seborrheic Keratosis, Skin Tag, Sneddon-Wilkinson disease, Urticaria, Vascular malformation, Verruca, Common Warts, Wells syndrome, WHIM syndrome, Xanthomas, Tuberous sclerosis, Davenport-Donlan syndrome, Gianotti-Crosti Syndrome, Dermatomyositis, MSBD syndrome (Skin Cancer), FLOTCH syndrome
Drug Side Effect	Etanercept , Methotrexate-associated lymphoproliferative disorders, Steroid abuse
Ear Nose Throat	Davenport-Donlan syndrome
Endocrine	Insulin-resistance syndrome type A, Sneddon-Wilkinson disease
Environmental	Heat rash, Sun spots, Temperature-related eczema
Gastroenterologic	Gastrointestinal Basidiobolomycosis, Primary biliary cirrhosis
Genetic	Congenital hypotrichosis milia, Cowden's syndrome, Familial Eosinophilic Cellulitis, Guizar-Vasquez-Luengas syndrome, Hereditary hemorrhagic telangiectasis, Incontinentia Pigmenti, Jadassohn-Lewandowsky syndrome, Lewandowsky-Lutz dysplasia, Metachondromatosis, Multiple fibrofolliculoma familial, Puretic syndrome, Roch-Leri mesosomatous lipomatosis
Hematologic	Anaplastic large cell lymphoma, Anaplastic small cell lymphoma, Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency, Cutaneous mastocytosis, Eosinophilic pustular folliculitis, Mastocytosis - skin bumps, Multicentric reticulohistiocytosis, Primary cutaneous CD30-positive T-cell lymphoproliferative disorders, Primary Lymphatic Obstruction, Secondary Lymphatic Obstruction, T-cell lymphoma 1A, Aleukemic leukemia cutis, Lymphoma, WHIM syndrome
Iatrogenic	No underlying causes
Infectious Disease	Bacteria: Abscess, Cutaneous Anthrax, Gianotti-Crosti Syndrome, Leprosy, MRSA, Mycobacterium abscessus, Mycobacterium haemophilum, Pyoderma gangrenosum, Pyogenic granuloma, Pinta, Scarlet Fever, Syphilis, Yaws Virus: Condyloma, Genital herpes, HIV, Human Papillomavirus, Mansonella streptocerca infection, Molluscum Contagiosum, Orf Fungi: Tinea Parasites: Cysticercosis, Demodicidosis, Paragonimiasis, River blindness, Sporotrichosis, Trichosporon, Scabies
Musculoskeletal / Ortho	Dermatomyositis, Mixed sclerosing bone dystrophy, MSBD syndrome, Multicentric osteolysis -- nodulosis -- arthropathy, Nodulosis-arthropathy-osteolysis syndrome, Palindromic rheumatism, Neurofibromatosis-Noonan syndrome
Neurologic	Neurofibromatosis, Neurofibromatosis-Noonan syndrome, Tuberous sclerosis
Nutritional / Metabolic	Fucosidosis type II
Obstetric/Gynecologic	No underlying causes
Oncologic	Abdominal Cancer, Acrospiroma, Adult Fibrosarcoma, Aleukemic leukemia cutis, Basal Cell Carcinoma (Skin Cancer), Dermal melanoma, Dermatofibroma, Dermoid cyst, Desmoid tumor, Infantile Fibrosarcoma, Infantile myofibromatosis, Kaposi sarcoma, Keratoacanthoma, Lip cancer, Lymphoma, Malignant melanoma, Merkel cell cancer, Metastatic Carcinoma, Multiple keratoacanthoma, Ferguson-Smith type, Papilloma, Secondary skin tumor, Soft Tissue Sarcomas, Squamous Cell Carcinoma (Skin Cancer), Trichofolliculoma, Anaplastic large cell lymphoma, Anaplastic small cell lymphoma
Opthalmologic	Cataract, alopecia, sclerodactyly
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Wegener's granulomatosis
Renal / Electrolyte	FLOTCH syndrome, Nephrogenic Fibrosing Dermopathy, Wegener's granulomatosis
Rheum / Immune / Allergy	Autosensitization dermatitis, Bubble bath allergy, Cercarial dermatitis, Contact Dermatitis, Gout, Irritant contact eczema, Limited cutaneous systemic sclerosis, Pemphigus and fogo selvagem, Rheumatoid Arthritis, Seronegative arthritis, Soap allergy, Sunscreen allergy, Cataract, alopecia, sclerodactyly, Allergic contact dermatitis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Boil, Cavernous hemangioma, Cysts, Enlarged Lymph Nodes, Erucism, Hemangioma, Hyperplasia, Insect Sting Allergies, Keloid, Lepidopterism, Leprosy-like acne skin symptoms, Lipoid proteinosis of Urbach and Wiethe, Lipoma, Lubarsch-Pick syndrome, Lymphatic Obstruction, Lymphomatoid Granulomatosis, Neurofibroma, Polymorphic Light Eruption, Port wine stain, Pseudoxanthoma elasticum, Rash, Recurring Boil, Rombo syndrome, Spider nevi, Splinters or Other Foreign Bodies, Strawberry nevi, Stress-related eczema

Causes in Alphabetical Order

Abdominal Cancer Abscess Acne Vulgaris Acrospiroma Actinic Keratosis Adult Fibrosarcoma Aleukemic leukemia cutis Allergic contact dermatitis Anaplastic large cell lymphoma Anaplastic small cell lymphoma Atopic dermatitis Autosensitization dermatitis Basal Cell Carcinoma (Skin Cancer) Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency Boil Bubble bath allergy Campbell de Morgan spots Cataract - alopecia - sclerodactyly Cavernous hemangioma Cercarial dermatitis Cherry angioma Median cleft upper lip-- cutaneous polyps Condyloma Congenital hypotrichosis milia Contact Dermatitis Cowden's syndrome Cutaneous Anthrax Cutaneous mastocytosis Cysticercosis Cysts Davenport-Donlan syndrome Demodicidosis Dermal melanoma Dermatofibroma Dermatomyositis Dermoid cyst Desmoid tumor Eczema Enlarged Lymph Nodes Eosinophilic pustular folliculitis Erucism Erythema elevatum diutinum Erythema Nodosum Etanercept Familial Eosinophilic Cellulitis Febrile Ulceronecrotic Mucha-Habermann disease FLOTCH syndrome Follicular hamartoma -- alopecia -- cystic fibrosis Folliculitis Fucosidosis type II - warty skin growths Fungal infections Ganglion Gastrointestinal Basidiobolomycosis - painless nodule or lump underneath the skin Genital herpes Gianotti-Crosti Syndrome Gout Granuloma Annulare Guizar-Vasquez-Luengas syndrome

Hashimoto-Pritzker syndrome Heat rash Hemangioma Hereditary hemorrhagic telangiectasis HIV Human Papillomavirus Hyperplasia Impetigo Incontinentia Pigmenti Infantile Fibrosarcoma Infantile myofibromatosis Insect Sting Allergies Insulin-resistance syndrome type A Intradermal Cyst Irritant contact eczema Jadassohn-Lewandowsky syndrome Kaposi sarcoma Keloid Keratoacanthoma Keratosis Pilaris Lepidopterism Leprosy Leprosy-like acne skin symptoms Lewandowsky-Lutz dysplasia Limited cutaneous systemic sclerosis Lip cancer Lipoid proteinosis of Urbach and Wiethe Lipoma Lubarsch-Pick syndrome Lymphatic Obstruction Lymphoma Lymphomatoid Granulomatosis Malignant melanoma Mansonella streptocerca infection Mastocytosis Merkel cell cancer Metachondromatosis Metastatic Carcinoma Methotrexate-associated lymphoproliferative disorders Mixed sclerosing bone dystrophy Moles Molluscum Contagiosum MRSA MSBD syndrome Multicentric osteolysis -- nodulosis -- arthropathy Multicentric reticulohistiocytosis Multiple fibrofolliculoma familial Multiple keratoacanthoma-Ferguson-Smith type Mycobacterium abscessus Mycobacterium haemophilum Nephrogenic Fibrosing Dermopathy Neurofibroma Neurofibromatosis Neurofibromatosis-Noonan syndrome Nodulosis-arthropathy-osteolysis syndrome Orf Palindromic rheumatism Papilloma

Papular mucinosis Paragonimiasis Pemphigus and fogo selvagem Pinta Polymorphic Light Eruption Port wine stain Primary biliary cirrhosis - skin cholesterol deposits Primary cutaneous CD30-positive T-cell lymphoproliferative disorders Primary Lymphatic Obstruction Pseudoxanthoma elasticum Puretic syndrome Pyoderma gangrenosum Pyogenic granuloma Rash Recurring Boil Rheumatoid Arthritis River blindness Roch-Leri mesosomatous lipomatosis Rombo syndrome Rosacea Scabies Scarlet Fever Scleromyxedema Sebaceous (Epidermoid) Cysts Seborrheic Keratosis Secondary Lymphatic Obstruction Secondary skin tumor Seronegative Arthritis Skin Tag Sneddon-Wilkinson disease Soap allergy Soft Tissue Sarcomas Spider nevi Splinters or Other Foreign Bodies Sporotrichosis Squamous Cell Carcinoma (Skin Cancer) Steroid Abuse Strawberry nevi Stress-related eczema Sun spots Sunscreen allergy Syphilis T-cell lymphoma 1A Temperature-related eczema Trichofolliculoma Trichosporon Tuberous sclerosis Urticaria Verruca Warts Wegener's granulomatosis Wells syndrome WHIM syndrome Xanthomas Yaws