Reticulum cell sarcoma: Difference between revisions
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==Overview== | ==Overview== | ||
A malignant tumor of reticular tissue that is composed primarily of neoplastic [[histocytes]]. | A malignant tumor of reticular tissue in the bone that is composed primarily of neoplastic [[histocytes]]. | ||
==Pathophysiology== | |||
The dominant cell type is thought to be derived from [[histiocytes]] or [[macrophages]]. More recent thinking indicates that this cancer may arise from [[lymphocytes]] or [[immunoblasts]]. | |||
==Epidemiology and Demographics== | |||
*Presents in middle age | |||
==Diagnosis== | |||
===Symptoms=== | |||
*Localized bone pain and tenderness | |||
===Physical Examination=== | |||
*Tenderness of bone | |||
*Effusion of adjacent joint | |||
===Imaging Findings=== | |||
*Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone | |||
===Pathology=== | |||
*Large, foam filled [[histiocytes]] with numerous [[mitoses]] and scant stroma are present | |||
*Stains for reticulum are positive | |||
*[[Periodic Acid Schiff]] ([[PAS]]) stains are negative | |||
==Treatment== | |||
===Early stage I tumors=== | |||
*[[Radiation therapy]] alone | |||
===Advanced Tumors=== | |||
*[[Radiation therapy]] plus [[chemotherapy]] | |||
==References== | ==References== | ||
Revision as of 22:59, 15 July 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Keywords and synonyms: histiocytic lymphoma, histiocytic lymphosarcoma
Overview
A malignant tumor of reticular tissue in the bone that is composed primarily of neoplastic histocytes.
Pathophysiology
The dominant cell type is thought to be derived from histiocytes or macrophages. More recent thinking indicates that this cancer may arise from lymphocytes or immunoblasts.
Epidemiology and Demographics
- Presents in middle age
Diagnosis
Symptoms
- Localized bone pain and tenderness
Physical Examination
- Tenderness of bone
- Effusion of adjacent joint
===Imaging Findings===
- Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone
Pathology
- Large, foam filled histiocytes with numerous mitoses and scant stroma are present
- Stains for reticulum are positive
- Periodic Acid Schiff (PAS) stains are negative
Treatment
Early stage I tumors
- Radiation therapy alone
Advanced Tumors