Cat scratch fever pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
[[Image: | [[Image:Cat_scratch_disease.jpg|thumb|right|High magnification [[micrograph]] of cat scratch disease showing a [[granuloma]] (pale cells - right of center on image) and a micro[[abscess]] with [[neutrophil]]s (left of image). [[H&E stain]].]] | ||
The primary cutaneous lesion consists of a red papule at site of inoculation, 1–2 weeks after contact, which may become pustular or crusted, which is accompanied by | The primary cutaneous lesion consists of a red papule at site of inoculation, 1–2 weeks after contact, which may become pustular or crusted, which is accompanied by | ||
Revision as of 15:13, 6 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
The primary cutaneous lesion consists of a red papule at site of inoculation, 1–2 weeks after contact, which may become pustular or crusted, which is accompanied by enlargement of regional – usually the cervical and axiallary – lymph nodes. Under the microscope, the skin lesion demonstrates a circumscribed focus of necrosis, surround by histiocytes, often accompanied by multinucleated giant cells, lymphocytes, and eosinophils. The regional lymph nodes demonstrate follicular hyperplasia with central stellate necrosis with neutrophils, surrounded by palisading histiocytes (suppurative granulomas) and sinuses packed with monocytoid B cells, usually without perifollicular and intrafollicular epithelioid cells
The Warthin–Starry stain is used to confirm the presence of B. henselæ.