Adenylate kinase: Difference between revisions
No edit summary |
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +)) |
||
| Line 18: | Line 18: | ||
}} | }} | ||
{{SI}} | {{SI}} | ||
==Overview== | ==Overview== | ||
| Line 36: | Line 36: | ||
{{Kinases}} | {{Kinases}} | ||
{{Mitochondrial enzymes}} | {{Mitochondrial enzymes}} | ||
[[ca:Mioquinasa]] | [[ca:Mioquinasa]] | ||
Latest revision as of 20:44, 8 August 2012
| Adenylate kinase 1 | |
|---|---|
| Identifiers | |
| Symbol | AK1 |
| Entrez | 203 |
| HUGO | 361 |
| OMIM | 103000 |
| RefSeq | NM_000476 |
| UniProt | P00568 |
| Other data | |
| EC number | 2.7.4.3 |
| Locus | Chr. 9 q34.1 |
|
WikiDoc Resources for Adenylate kinase |
|
Articles |
|---|
|
Most recent articles on Adenylate kinase Most cited articles on Adenylate kinase |
|
Media |
|
Powerpoint slides on Adenylate kinase |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Adenylate kinase at Clinical Trials.gov Trial results on Adenylate kinase Clinical Trials on Adenylate kinase at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Adenylate kinase NICE Guidance on Adenylate kinase
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Adenylate kinase Discussion groups on Adenylate kinase Patient Handouts on Adenylate kinase Directions to Hospitals Treating Adenylate kinase Risk calculators and risk factors for Adenylate kinase
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Adenylate kinase |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Overview
Adenylate kinase (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis (see the "Biological homeostasis" section of "Homeostasis"). The reaction catalyzed is:
2 ADP ⇔ ATP + AMP
The equilibrium constant in the direction written is 0.44. Thus, the ΔGo for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of ATP is typically 7-10 times that of ADP, and usually greater than 100 times that of AMP [1]. The rate of oxidative phosphorylation is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep ATP levels high due to the combined action of adenylate kinase and the controls on oxidative phosphorylation.
References
- ↑ Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.
External links
- Adenylate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)