Aminophylline: Difference between revisions
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Revision as of 22:05, 8 August 2012
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| Clinical data | |
|---|---|
| Routes of administration | oral, i.v. |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 60% |
| Elimination half-life | 7-9 hours |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C16H24N10O4 |
| Molar mass | 420.427 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.
Properties
It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.
Mechanism of action
Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.
Brand names
- Phyllocontin
- Truphylline