CYP4A11

Cytochrome P450, family 4, subfamily A, polypeptide 11
Identifiers
Symbols	CYP4A11 ; CP4Y; CYP4A2; CYP4AII
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88341
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for CYP4A11
Articles
Most recent articles on CYP4A11 Most cited articles on CYP4A11 Review articles on CYP4A11 Articles on CYP4A11 in N Eng J Med, Lancet, BMJ
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Guidelines / Policies / Govt
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News
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Commentary
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Definitions
Definitions of CYP4A11
Patient Resources / Community
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Experimental / Informatics
List of terms related to CYP4A11

Cytochrome P450, family 4, subfamily A, polypeptide 11, also known as CYP4A11, is a human gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

Further reading

• Kawashima H, Kusunose E, Kubota I; et al. (1992). "Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases". Biochim. Biophys. Acta. 1123 (2): 156–62. PMID 1739747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palmer CN, Richardson TH, Griffin KJ; et al. (1993). "Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli". Biochim. Biophys. Acta. 1172 (1–2): 161–6. PMID 7679927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawashima H, Kusunose E, Kikuta Y; et al. (1995). "Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase". J. Biochem. 116 (1): 74–80. PMID 7798189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imaoka S, Ogawa H, Kimura S, Gonzalez FJ (1994). "Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney". DNA Cell Biol. 12 (10): 893–9. PMID 8274222.CS1 maint: Multiple names: authors list (link)
• Bell DR, Plant NJ, Rider CG; et al. (1993). "Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs". Biochem. J. 294 ( Pt 1): 173–80. PMID 8363569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powell PK, Wolf I, Lasker JM (1996). "Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes". Arch. Biochem. Biophys. 335 (1): 219–26. doi:10.1006/abbi.1996.0501. PMID 8914854.CS1 maint: Multiple names: authors list (link)
• Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11". J. Pharmacol. Exp. Ther. 285 (3): 1327–36. PMID 9618440.CS1 maint: Multiple names: authors list (link)
• Chang YT, Loew GH (1999). "Homology modeling and substrate binding study of human CYP4A11 enzyme". Proteins. 34 (3): 403–15. PMID 10024026.
• Lasker JM, Chen WB, Wolf I; et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11". J. Biol. Chem. 275 (6): 4118–26. PMID 10660572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawashima H, Naganuma T, Kusunose E; et al. (2000). "Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein". Arch. Biochem. Biophys. 378 (2): 333–9. doi:10.1006/abbi.2000.1831. PMID 10860550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoch U, Ortiz De Montellano PR (2001). "Covalently linked heme in cytochrome p4504a fatty acid hydroxylases". J. Biol. Chem. 276 (14): 11339–46. doi:10.1074/jbc.M009969200. PMID 11139583.
• Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D (2001). "Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation". Br. J. Dermatol. 145 (5): 749–57. PMID 11736898.CS1 maint: Multiple names: authors list (link)
• LeBrun LA, Hoch U, Ortiz de Montellano PR (2002). "Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family". J. Biol. Chem. 277 (15): 12755–61. doi:10.1074/jbc.M112155200. PMID 11821421.CS1 maint: Multiple names: authors list (link)
• Savas U, Hsu MH, Johnson EF (2003). "Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone". Arch. Biochem. Biophys. 409 (1): 212–20. PMID 12464261.CS1 maint: Multiple names: authors list (link)
• Bellamine A, Wang Y, Waterman MR; et al. (2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Arch. Biochem. Biophys. 409 (1): 221–7. PMID 12464262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramírez J, Innocenti F, Schuetz EG; et al. (2005). "CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes". Drug Metab. Dispos. 32 (9): 930–6. PMID 15319333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gainer JV, Bellamine A, Dawson EP; et al. (2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation. 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayer B, Lieb W, Götz A; et al. (2005). "Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy". Hypertension. 46 (4): 766–71. doi:10.1161/01.HYP.0000182658.04299.15. PMID 16144986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)