Calicheamicin: Difference between revisions
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'''Calicheamicin''' is an antibiotic derived from organism [[Micromonospora echinospora]]. It was isolated originally from a rock collected in [[Waco, Texas]] by a hiking [[The Scripps Research Institute|Scripps Institute]] chemist. | '''Calicheamicin''' is an antibiotic derived from organism [[Micromonospora echinospora]]. It was isolated originally from a rock collected in [[Waco, Texas]] by a hiking [[The Scripps Research Institute|Scripps Institute]] chemist. | ||
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Latest revision as of 23:22, 8 August 2012
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Calicheamicin is an antibiotic derived from organism Micromonospora echinospora. It was isolated originally from a rock collected in Waco, Texas by a hiking Scripps Institute chemist.
It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. Gemtuzumab).
References
- http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html
- J Antibiot (Tokyo). 1989 Jul;42(7):1070-87.