Detoxication: Difference between revisions
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The major metabolites formed from most [[drug metabolism]] are '''detoxication products'''. | The major metabolites formed from most [[drug metabolism]] are '''detoxication products'''. | ||
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#A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity. | #A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity. | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Latest revision as of 00:39, 9 August 2012
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The major metabolites formed from most drug metabolism are detoxication products.
There are two common patterns observed:
- A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
- A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.