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'''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]].
'''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]].

Revision as of 00:43, 9 August 2012

Diazoxide detailed information
Clinical data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration		Oral, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding90%
MetabolismHepatic oxidation and sulfate conjugation
Elimination half-life21-45 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC8H7ClN2O2S
Molar mass230.672 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).


Template:WikiDoc Sources

de:Diazoxid hr:Diazoksid

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