Enteropeptidase: Difference between revisions
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'''Enteropeptidase''' or '''enterokinase''' is an [[enzyme]] involved in human [[digestion]]. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the [[crypts of Lieberkühn]], whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning [[trypsinogen]] (a [[zymogen]]) to [[trypsin]], indirectly activating a number of [[pancreas|pancreatic]] digestive enzymes. | '''Enteropeptidase''' or '''enterokinase''' is an [[enzyme]] involved in human [[digestion]]. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the [[crypts of Lieberkühn]], whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning [[trypsinogen]] (a [[zymogen]]) to [[trypsin]], indirectly activating a number of [[pancreas|pancreatic]] digestive enzymes. | ||
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Revision as of 02:16, 9 August 2012
| protease, serine, 7 (enterokinase) | |
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 Crystal structure of Enteropeptidase with an inhibitor | |
| Identifiers | |
| Symbol | PRSS7 |
| Entrez | 5651 |
| HUGO | 9490 |
| OMIM | 606635 |
| RefSeq | NM_002772 |
| UniProt | P98073 |
| Other data | |
| Locus | Chr. 21 q21 |
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WikiDoc Resources for Enteropeptidase |
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Most recent articles on Enteropeptidase Most cited articles on Enteropeptidase |
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Powerpoint slides on Enteropeptidase |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on Enteropeptidase at Clinical Trials.gov Trial results on Enteropeptidase Clinical Trials on Enteropeptidase at Google
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US National Guidelines Clearinghouse on Enteropeptidase NICE Guidance on Enteropeptidase
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Definitions |
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Patient Resources / Community |
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Patient resources on Enteropeptidase Discussion groups on Enteropeptidase Patient Handouts on Enteropeptidase Directions to Hospitals Treating Enteropeptidase Risk calculators and risk factors for Enteropeptidase
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Healthcare Provider Resources |
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Causes & Risk Factors for Enteropeptidase |
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Continuing Medical Education (CME) |
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Experimental / Informatics |
Enteropeptidase or enterokinase is an enzyme involved in human digestion. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the crypts of Lieberkühn, whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning trypsinogen (a zymogen) to trypsin, indirectly activating a number of pancreatic digestive enzymes.
Enteropeptidase is a serine protease enzyme (EC 3.4.21.9). Enteropeptidase is a part of the Chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.
Reaction
The reaction catalysed by Enteropeptidase:
trypsinogen → trypsin + octapeptide
Enterokinase cleaves after Lysine if the Lys is preceded by four Asp and not followed by a Pro. [1]
Nomenclature
Despite its older name of enterokinase, the enzyme is not a kinase, since it activates its substrate by cleavage and not phosphorylation.
Genetics
Enteropeptidase is encoded by the PRSS7 (serine protease-7 gene) or ENTK gene on the 21st chromosome (21q21).
Isolated cases of enterokinase deficiency have been reported.[2]
References
- ↑ "Enterokinase, light chain (P8070), Proteases, NEB". Retrieved 2007-10-04.
- ↑ Holzinger A, Maier EM, Bück C; et al. (2002). "Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency". Am. J. Hum. Genet. 70 (1): 20–5. PMID 11719902.
External links
- Enteropeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)