G418: Difference between revisions
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'''G418''' (also known as '''Geneticin''') is an [[aminoglycoside]] [[antibiotic]] similar in structure to [[gentamicin B1]]. It is produced by ''[[Micromonospora rhodorangea]]''. G418 blocks [[polypeptide synthesis]] by inhibiting the elongation step in both [[prokaryotic]] and [[eukaryotic]] cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II. G418 is commonly used in laboratory research to select genetically engineered cells. | '''G418''' (also known as '''Geneticin''') is an [[aminoglycoside]] [[antibiotic]] similar in structure to [[gentamicin B1]]. It is produced by ''[[Micromonospora rhodorangea]]''. G418 blocks [[polypeptide synthesis]] by inhibiting the elongation step in both [[prokaryotic]] and [[eukaryotic]] cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II. G418 is commonly used in laboratory research to select genetically engineered cells. | ||
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Latest revision as of 02:56, 9 August 2012
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WikiDoc Resources for G418 |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on G418 at Clinical Trials.gov Clinical Trials on G418 at Google
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US National Guidelines Clearinghouse on G418
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Directions to Hospitals Treating G418 Risk calculators and risk factors for G418
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G418 (also known as Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II. G418 is commonly used in laboratory research to select genetically engineered cells.