Guanethidine: Difference between revisions
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==[[Guanethidine (patient information)|For patient information, click here]]== | ==[[Guanethidine (patient information)|For patient information, click here]]== |
Revision as of 15:42, 9 August 2012
Clinical data | |
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ATC code | |
Pharmacokinetic data | |
Elimination half-life | 1.5 days |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C10H22N4 |
Molar mass | 198.309 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
For patient information, click here
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as noradrenaline. Its mechanism is inhibition of the Mg++ATPase dependent pump. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea.
It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a hypertensive emergency.
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