Herbimycin: Difference between revisions
m Protected "Herbimycin": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)) |
m Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +) |
||
| Line 89: | Line 89: | ||
}} | }} | ||
{{SI}} | {{SI}} | ||
'''Herbimycin''' is a [[benzoquinone]] [[ansamycin]] [[antibiotic]] that binds to [[Hsp90]] (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, [[apoptosis]], [[angiogenesis]] and [[oncogenesis]]. | '''Herbimycin''' is a [[benzoquinone]] [[ansamycin]] [[antibiotic]] that binds to [[Hsp90]] (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, [[apoptosis]], [[angiogenesis]] and [[oncogenesis]]. | ||
| Line 108: | Line 108: | ||
[[Category:Quinones]] | [[Category:Quinones]] | ||
{{WH}} | {{WH}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 15:57, 9 August 2012
|
WikiDoc Resources for Herbimycin |
|
Articles |
|---|
|
Most recent articles on Herbimycin |
|
Media |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Herbimycin at Clinical Trials.gov Clinical Trials on Herbimycin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Herbimycin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Herbimycin Discussion groups on Herbimycin Patient Handouts on Herbimycin Directions to Hospitals Treating Herbimycin Risk calculators and risk factors for Herbimycin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Herbimycin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
It was originally found by its herbicidal activity, and thus named.
Synonyms
- Antibiotic Tan 420F
- Herbimycin A
Biological activity
Herbimycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90.
See also