Mechlorethamine (topical): Difference between revisions
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Revision as of 17:14, 9 August 2012
| File:Mechlorethamine.png | |
| Clinical data | |
|---|---|
| Pregnancy category |
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| Routes of administration | IV, intracavitary, intrapericardially, topical |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Rapid hydrolysis and demethylation, possibly in plasma |
| Elimination half-life | < 1 minute |
| Excretion | Urine (50% as metabolites, <0.01% as unchanged drug) |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C5H11Cl2N |
| Molar mass | 156.055 g mol−1 |
Overview
Mechlorethamine also known as chlormethine, mustine, nitrogen mustard and HN2 and sold under the brand name Mustargen, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from chemical warfare research, in particular a 1943 accident in Bari, Italy which exposed civilians and soldiers-- it was noted that white cell counts of exposed patients decreased, suggesting a possible therapy for the cancer Hodgkin's lymphoma. It belongs to the group of nitrogen mustard alkylating agents.
It has been derivatized into the estrogen analogue estramustine, used to treat prostate cancer.
It can also be used in chemical warfare where it has the code-name HN2. This chemical is a form of nitrogen mustard gas and therefore a powerful vesicant.
External links
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- E number from Wikidata
- ECHA InfoCard ID from Wikidata
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- Chemotherapeutic agents