Nephrotoxic drugs: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
*[[Acyclovir]] (only nephrotoxic in intravenous form) | *[[Acyclovir]] (only nephrotoxic in intravenous form) | ||
*[[Aminoglycosides]] (10-15% Incidence of Acute Tubular Necrosis) | *[[Aminoglycosides]] (10-15% Incidence of Acute Tubular Necrosis) | ||
:* Occurs in 10-20% patients on 7 day course | :*Occurs in 10-20% patients on 7 day course | ||
:* Results in non-oligurics; increased [[Creatinine]] | :*Results in non-oligurics; increased [[Creatinine]] | ||
:* A single dose early in septic course is usually safe | :*A single dose early in septic course is usually safe | ||
*[[Amphotericin B]] (Incidence 80-90%) | *[[Amphotericin B]] (Incidence 80-90%) | ||
*[[Ciprofloxacin]] | *[[Ciprofloxacin]] | ||
*[[Chloroquine]] | *[[Chloroquine]] | ||
*[[Erythromycin]] | *[[Erythromycin]] | ||
*[[Foscarnet]] | |||
*[[Gentamycin]] | *[[Gentamycin]] | ||
*[[Hydroxychloroquine]] | *[[Hydroxychloroquine]] | ||
*[[Indinavir]] | |||
*[[Isoniazide]] | |||
*[[Levofloxacin]] | *[[Levofloxacin]] | ||
*[[Methicillin]] | |||
*[[Pentamidine]] | *[[Pentamidine]] | ||
*[[Quinine]] | |||
*[[Rifampin]] | *[[Rifampin]] | ||
*[[Sulfonamides]] | *[[Sulfonamides]] | ||
*[[Tetracycline]] | *[[Tetracycline]] | ||
*[[Tenofovir]] | |||
*[[Trimethadione]] | |||
*[[Vancomycin]] | |||
==Chemotherapy and Immunosuppressants== | ==Chemotherapy and Immunosuppressants== | ||
| Line 30: | Line 38: | ||
*[[Mitomycin]] | *[[Mitomycin]] | ||
*[[Foscarnet]] | *[[Foscarnet]] | ||
*[[Tacrolimus]] | |||
== Heavy Metals== | == Heavy Metals and Poisons== | ||
* [[Arsenic]] Poisoning | *[[Arsenic]] Poisoning | ||
* [[Bismuth]] | *[[Bismuth]] | ||
* [[Lead]] Poisoning | *[[Lead]] Poisoning | ||
* [[Lithium]] related kidney disorders | *[[Lithium]] related kidney disorders | ||
:* [[Polydipsia]] and [[Nephrogenic Diabetes Insipidus]] | :*[[Polydipsia]] and [[Nephrogenic Diabetes Insipidus]] | ||
:* [[Acute Renal Failure]] | :*[[Acute Renal Failure]] | ||
:*:* [[Dialysis]] indications: [[Creatinine]] >2.5 or [[Seizure]]s, ALOC, [[Rhabdomyolysis]] | :*:*[[Dialysis]] indications: [[Creatinine]] >2.5 or [[Seizure]]s, ALOC, [[Rhabdomyolysis]] | ||
:* [[Chronic kidney disease]] with [[fibrosis]] | :*[[Chronic kidney disease]] with [[fibrosis]] | ||
* [[Mercury]] Poisoning | *[[Mercury]] Poisoning | ||
*[[Nitrosourea compounds]] | |||
==AntiHyperlipidemics== | ==AntiHyperlipidemics== | ||
* [[Fenofibrate]] (Tricor) | *[[Fenofibrate]] (Tricor) | ||
:* Increases | :*Increases [[serum creatinine]] without significant decrease in [[GFR]] | ||
:* | :*[[Serum creatinine]] rise is reversible on stopping [[Fenofibrate]] | ||
* [[Gemfibrozil]] | *[[Gemfibrozil]] | ||
:* Associated with [[Acute Renal Failure]] due to [[Rhabdomyolysis]] | :*Associated with [[Acute Renal Failure]] due to [[Rhabdomyolysis]] | ||
* [[Statin]]s | *[[Statin]]s | ||
==Chemotherapy== | ==Chemotherapy== | ||
*[[Carmustine]] | *[[Carmustine]] | ||
*[[Carboplatin]] | *[[Carboplatin]] | ||
* [[Cisplatin]] | *[[Cisplatin]] | ||
* [[Ifosfamide]] | *[[Ifosfamide]] | ||
:* Causes [[Fanconi's Syndrome]] | :* Causes [[Fanconi's Syndrome]] | ||
*[[Lomustine]] | |||
==Proton channel blockers== | |||
*[[Esmoprazole]] | |||
*[[Lansoprazole]] | |||
*[[Omeprazole]] | |||
*[[Pantoprazole]] | |||
*[[Rabeprazole]] | |||
==Miscellaneous Drugs== | ==Miscellaneous Drugs== | ||
* Chronic stimulant [[Laxative]] use | * Chronic stimulant [[Laxative]] use | ||
:* Resulting chronic volume depletion and [[Hypokalemia]] causes [[nephropathy]] | :* Resulting chronic volume depletion and [[Hypokalemia]] causes [[nephropathy]] | ||
| Line 66: | Line 83: | ||
*[[Acetaminophen]] | *[[Acetaminophen]] | ||
*[[Anticoagulants]] | *[[Anticoagulants]] | ||
* [[Allopurinol]] | *[[Allopurinol]] | ||
* [[Aspirin]] | *[[Aspirin]] | ||
:* Low dose [[Aspirin]] reduces [[Renal function]] in elderly | :* Low dose [[Aspirin]] reduces [[Renal function]] in elderly | ||
:*:* Decreased [[Creatinine Clearance]] after 2 weeks of use | :*:* Decreased [[Creatinine Clearance]] after 2 weeks of use | ||
:*:* Changes persisted for at least 3 weeks off [[Aspirin]] | :*:* Changes persisted for at least 3 weeks off [[Aspirin]] | ||
*[[Bivacizumab]] | |||
*[[Carbon tetrachloride]] | *[[Carbon tetrachloride]] | ||
* [[Cimetidine]] | *[[Cimetidine]] | ||
* [[Ciprofloxacin]] | *[[Ciprofloxacin]] | ||
* [[Dilantin]] | *[[Dilantin]] | ||
* [[Diuretic]]s | *[[Diuretic]]s | ||
:*[[Thiazide]]s | :*[[Thiazide]]s | ||
:*[[Furosemide]] | :*[[Furosemide]] | ||
* [[Mesalamine]] (Asacol, Pentasa) | *[[Infliximab]] | ||
*[[Interferon]]s | |||
*[[Mesalamine]] (Asacol, Pentasa) | |||
:*:* [[Mesalamine]] is an [[NSAID]] analog and has systemic absorption from the bowel | :*:* [[Mesalamine]] is an [[NSAID]] analog and has systemic absorption from the bowel | ||
* [[NSAID]]s: [[Celecoxib]] | *[[NSAID]]s: [[Celecoxib]], [[Ibuprofen]], [[Naproxen]] | ||
:* [[Nephrotic Syndrome]] type reaction | :*[[Nephrotic Syndrome]] type reaction | ||
* [[Penicillin]]s and [[Cephalosporin]]s | *[[Penicillin]]s and [[Cephalosporin]]s | ||
:* [[Hypersensitivity]] ([[fever]], [[rash]], [[arthralgia]]) | *[[Pamidronate]] | ||
* [[Rifampin]] | *[[Propylthiouracil]] | ||
* [[Sulfonamide]]s | :*[[Hypersensitivity]] ([[fever]], [[rash]], [[arthralgia]]) | ||
:* [[Vasculitis]] reaction | *[[Rifampin]] | ||
*[[Sulfonamide]]s | |||
:*[[Vasculitis]] reaction | |||
==Drugs of abuse== | ==Drugs of abuse== | ||
Revision as of 22:06, 9 August 2012
|
WikiDoc Resources for Nephrotoxic drugs |
|
Articles |
|---|
|
Most recent articles on Nephrotoxic drugs Most cited articles on Nephrotoxic drugs |
|
Media |
|
Powerpoint slides on Nephrotoxic drugs |
|
Evidence Based Medicine |
|
Cochrane Collaboration on Nephrotoxic drugs |
|
Clinical Trials |
|
Ongoing Trials on Nephrotoxic drugs at Clinical Trials.gov Trial results on Nephrotoxic drugs Clinical Trials on Nephrotoxic drugs at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Nephrotoxic drugs NICE Guidance on Nephrotoxic drugs
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Nephrotoxic drugs Discussion groups on Nephrotoxic drugs Patient Handouts on Nephrotoxic drugs Directions to Hospitals Treating Nephrotoxic drugs Risk calculators and risk factors for Nephrotoxic drugs
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Nephrotoxic drugs |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Nephrotoxic drugs are pharmacotherapies that can lead to a decline in renal function. The drug may need to be discontinued, or the dosing reduced when this happens.
Antibiotics
- Acyclovir (only nephrotoxic in intravenous form)
- Aminoglycosides (10-15% Incidence of Acute Tubular Necrosis)
- Occurs in 10-20% patients on 7 day course
- Results in non-oligurics; increased Creatinine
- A single dose early in septic course is usually safe
- Amphotericin B (Incidence 80-90%)
- Ciprofloxacin
- Chloroquine
- Erythromycin
- Foscarnet
- Gentamycin
- Hydroxychloroquine
- Indinavir
- Isoniazide
- Levofloxacin
- Methicillin
- Pentamidine
- Quinine
- Rifampin
- Sulfonamides
- Tetracycline
- Tenofovir
- Trimethadione
- Vancomycin
Chemotherapy and Immunosuppressants
Heavy Metals and Poisons
- Polydipsia and Nephrogenic Diabetes Insipidus
- Acute Renal Failure
- Dialysis indications: Creatinine >2.5 or Seizures, ALOC, Rhabdomyolysis
- Chronic kidney disease with fibrosis
- Mercury Poisoning
- Nitrosourea compounds
AntiHyperlipidemics
- Fenofibrate (Tricor)
- Increases serum creatinine without significant decrease in GFR
- Serum creatinine rise is reversible on stopping Fenofibrate
- Associated with Acute Renal Failure due to Rhabdomyolysis
Chemotherapy
- Causes Fanconi's Syndrome
Proton channel blockers
Miscellaneous Drugs
- Chronic stimulant Laxative use
- Resulting chronic volume depletion and Hypokalemia causes nephropathy
- Expect an increase of serum creatinine in chronic kidney disease
- Low dose Aspirin reduces Renal function in elderly
- Decreased Creatinine Clearance after 2 weeks of use
- Changes persisted for at least 3 weeks off Aspirin
- Low dose Aspirin reduces Renal function in elderly
- Infliximab
- Interferons
- Mesalamine (Asacol, Pentasa)
- Mesalamine is an NSAID analog and has systemic absorption from the bowel
- Nephrotic Syndrome type reaction
- Vasculitis reaction