Granulomatous angiitis: Difference between revisions
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==Overview== | ==Overview== | ||
Granulomatous angiitis is an uncommon necrotising vasculitis of unknown cause restricted to vessels of the central nervous system.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1033014/</ref> | Granulomatous angiitis is an uncommon necrotising vasculitis of unknown cause restricted to vessels of the central nervous system.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1033014/</ref> | ||
==Historical Perspective== | |||
Cravioto and Feigin defined granulomatous angiitis in 1959. | |||
==Pathophysiology== | |||
===Microscopic Pathology=== | |||
* It mainly involves small intracerebral vessels. | |||
* Microscopic changes include | |||
** Focal fibrinoid necrosis of the vessel wall | |||
** Variable inflammatory infiltrate( neutrophils , lymphocytes, epitheloid appearing histiocytes and multinucleated giant cells) forming granuloma in the wall of the vessel. | |||
** Ischemic or hemorrhagic changes may be seen in parenchyma distal to the segment involved. | |||
==References== | ==References== | ||
Revision as of 00:26, 10 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Granulomatous angiitis is an uncommon necrotising vasculitis of unknown cause restricted to vessels of the central nervous system.[1]
Historical Perspective
Cravioto and Feigin defined granulomatous angiitis in 1959.
Pathophysiology
Microscopic Pathology
- It mainly involves small intracerebral vessels.
- Microscopic changes include
- Focal fibrinoid necrosis of the vessel wall
- Variable inflammatory infiltrate( neutrophils , lymphocytes, epitheloid appearing histiocytes and multinucleated giant cells) forming granuloma in the wall of the vessel.
- Ischemic or hemorrhagic changes may be seen in parenchyma distal to the segment involved.