Addison's disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

Most common causes of Addison's disease include:

• Autoimmune/idiopathic
• Tuberculosis
• AIDS
• CMV
• Hemorrhage
• Infarction
• Sarcoidosis
• Infections

Causes by Organ System

Cardiovascular	Arteritis, Hypotension, Hemorrhage, Infarction
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Corticosteroid withdrawal
Ear Nose Throat	No underlying causes
Endocrine	Adrenal aplasia / hypoplasia, Adrenal metastases, After surgery of cortisol-secreting tumor, Bilateral adrenalectomy , Congenital adrenal hyperplasia, Glucocorticoid deficiency 1
Environmental	No underlying causes
Gastroenterologic	Hemochromatosis
Genetic	No underlying causes
Hematologic	Anticoagulation, Coagulopathy , Embolus, Leukemia, Lymphoma , Thrombosis
Iatrogenic	Iatrogenic, Radiation therapy
Infectious Disease	AIDS, Blastomycosis, CMV, Coccidiomycosis, Cryptococcosis, Histoplasmosis , Mycobacterium avium intracellulaire (MAI), Sepsis, Syphilis, Toxoplasmosis, Tuberculosis, Waterhouse-Friderichson syndrome
Musculoskeletal / Ortho	No underlying causes
Neurologic	Coma
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Kaposi's sarcoma, Leukemia, Lymphoma
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Sarcoidosis,
Renal / Electrolyte	Uremia, Waterhouse-Friderichson syndrome
Rheum / Immune / Allergy	Autoimmune, Sarcoidosis
Sexual	No underlying causes
Trauma	Trauma
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Amyloidosis, Idiopathic, Iatrogenic, Radiation therapy, Surgery

Causes in Alphabetical Order

Adrenal aplasia / hypoplasia Adrenal metastases AIDS Amyloidosis Anticoagulation Arteritis After surgery of cortisol-secreting tumor Autoimmune/idiopathic Bilateral adrenalectomy Blastomycosis CMV Coagulopathy Coccidiomycosis Congenital adrenal hyperplasia Cryptococcosis Coma Corticosteroid withdrawal Drugs Embolus Glucocorticoid deficiency 1 Hemochromatosis Histoplasmosis

Hypotension Hemorrhage, infarction Iatrogenic Kaposi's sarcoma Leukemia Lymphoma Mycobacterium avium intracellulaire (MAI) Neonatal Neoplasm Radiation therapy Sarcoidosis Sepsis Surgery Syphilis Thrombosis Toxoplasmosis Trauma Tuberculosis (20% of all Addison's) Uremia Waterhouse-Friderichson syndrome