Drug allergy erythema multiforme: Difference between revisions
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=== History and Symptoms === | === History and Symptoms === | ||
The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm. | The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm. [[Image:Erythema_multiforme_target_lesions.jpeg|right|Erythema multiforme target lesions]] | ||
== Diagnosis == | == Diagnosis == | ||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
Laboratory findings are non-specific and can include an elevated erythrocyte sedimentation rate ([[ESR]]), elevated white blood cell count ([[WBC]]), and elevated liver enzymes. | Laboratory findings are non-specific and can include an elevated erythrocyte sedimentation rate ([[ESR]]), elevated white blood cell count ([[WBC]]), and elevated liver enzymes. | ||
Revision as of 16:20, 16 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Drug allergy erythema multiforme On the Web |
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American Roentgen Ray Society Images of Drug allergy erythema multiforme |
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Risk calculators and risk factors for Drug allergy erythema multiforme |
Overview
Erythema multiforme is a skin condition of unknown etiology, but some authors suggest that the disease is mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane. It can occur due to drug exposure,as well in association with some types of infections. It varies from a mild, self-limited rash (E. multiforme minor) to a severe, life-threatening form (E. multiforme major, or Stevens-Johnson syndrome) that also involves mucous membranes.
Common Causes
E. multiforme may also be caused by drug reactions, most commonly sulfa drugs, phenytoin, barbiturates, penicillin, and allopurinol, or a host of internal ailments. The most common predisposing infection for E. multiforme is Herpes simplex, but bacterial infections (commonly Mycoplasma) and fungal diseases are also implicated.
History and Symptoms
The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm.
Diagnosis
Laboratory Findings
Laboratory findings are non-specific and can include an elevated erythrocyte sedimentation rate (ESR), elevated white blood cell count (WBC), and elevated liver enzymes.