Drug allergy natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
*[[Stevens-Johnson syndrome]] starts with a generalized [[macropapular]] | *[[Stevens-Johnson syndrome]] starts with a generalized [[macropapular rash]], that will then progress to bullae, mucous membrane [[ulcerations]], [[conjunctivitis]], [[fever]], [[sore throat]], and [[fatigue]]. | ||
*[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | *[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | ||
Revision as of 16:03, 17 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]
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Overview
Natural History
- Stevens-Johnson syndrome starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane ulcerations, conjunctivitis, fever, sore throat, and fatigue.
- Toxic epidermal necrolysis will progress similarly to Stevens-Johnson syndrome, but will also cause large layers of the epidermis to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding.