Cholinergic crisis: Difference between revisions
m (1 revision) |
No edit summary |
||
Line 1: | Line 1: | ||
{{ | {{SI}} | ||
{{CMG}} | |||
A '''cholinergic crisis''' is an over-stimulation at a [[neuromuscular junction]] due to an excess of [[acetylcholine]] (ACh), as of a result of the inactivity (perhaps even [[enzyme inhibition|inhibition]]) of the [[AChE]] [[enzyme]], which normally breaks down acetylcholine. This is a consequence of some types of [[nerve gas]], (e.g. [[sarin]] gas). In medicine, this is seen in patients with [[myasthenia gravis]] who take too high a dose of their cholinergic treatment medications, or seen in some surgical cases, when too high a dose of a cholinesterase inhibitor is given to reverse surgical muscle paralysis. | A '''cholinergic crisis''' is an over-stimulation at a [[neuromuscular junction]] due to an excess of [[acetylcholine]] (ACh), as of a result of the inactivity (perhaps even [[enzyme inhibition|inhibition]]) of the [[AChE]] [[enzyme]], which normally breaks down acetylcholine. This is a consequence of some types of [[nerve gas]], (e.g. [[sarin]] gas). In medicine, this is seen in patients with [[myasthenia gravis]] who take too high a dose of their cholinergic treatment medications, or seen in some surgical cases, when too high a dose of a cholinesterase inhibitor is given to reverse surgical muscle paralysis. | ||
As a result of cholinergic crisis, the muscles stop responding to the bombardment of ACh, leading to [[flaccid paralysis]], [[respiratory failure]], and other signs and symptoms reminiscent of [[organophosphate]] poisoning. Other symptoms include increased sweating, salivation, [[bronchia]]l secretions along with [[miosis]]. This crisis may be masked by the concomitant use of [[atropine]] along with anticholinesterase inhibitors in order to prevent side effects. | As a result of cholinergic crisis, the muscles stop responding to the bombardment of ACh, leading to [[flaccid paralysis]], [[respiratory failure]], and other signs and symptoms reminiscent of [[organophosphate]] poisoning. Other symptoms include increased sweating, salivation, [[bronchia]]l secretions along with [[miosis]]. This crisis may be masked by the concomitant use of [[atropine]] along with anticholinesterase inhibitors in order to prevent side effects. | ||
== See also== | == See also== | ||
[[SLUDGE syndrome]] | [[SLUDGE syndrome]] | ||
[[Category:Chemical pathology]] | [[Category:Chemical pathology]] | ||
[[Category:Neurotransmitters]] | [[Category:Neurotransmitters]] | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Medicinal chemistry]] | [[Category:Medicinal chemistry]] | ||
[[Category:Emergency medicine]] | |||
[[Category:Intensive care medicine]] | |||
[[pl:Przełom cholinergiczny]] | [[pl:Przełom cholinergiczny]] |
Revision as of 01:44, 19 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine (ACh), as of a result of the inactivity (perhaps even inhibition) of the AChE enzyme, which normally breaks down acetylcholine. This is a consequence of some types of nerve gas, (e.g. sarin gas). In medicine, this is seen in patients with myasthenia gravis who take too high a dose of their cholinergic treatment medications, or seen in some surgical cases, when too high a dose of a cholinesterase inhibitor is given to reverse surgical muscle paralysis.
As a result of cholinergic crisis, the muscles stop responding to the bombardment of ACh, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning. Other symptoms include increased sweating, salivation, bronchial secretions along with miosis. This crisis may be masked by the concomitant use of atropine along with anticholinesterase inhibitors in order to prevent side effects.