Peptic ulcer causes: Difference between revisions

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Revision as of 12:30, 19 August 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Comon Cuases

Causes in Alphabetical Order

References

Template:Gastroenterology

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 ==Comon Cuases==
-A major causative factor (60% of gastric and 90% of duodenal ulcers) is chronic [[inflammation]] due to ''[[Helicobacter pylori]]'' that colonizes (''i.e.'' settles there after entering the body) the [[Pyloric antrum|antral]] [[mucosa]]. The immune system is unable to clear the infection, despite the appearance of antibodies. Thus, the [[bacterium]] can cause a chronic active [[gastritis]] (type B gastritis), resulting in a defect in the regulation of [[gastrin]] production by that part of the stomach, and gastrin secretion is increased. [[Gastrin]], in turn, stimulates the production of [[gastric acid]] by parietal cells. The acid erodes the [[mucosa]] and causes the ulcer.
+*[[Helicobacter pylori]]
+*[[NSAID]]s
-Another major cause is the use of [[NSAID]]s (see above). The gastric mucosa protects itself from [[gastric acid]] with a layer of mucus, the secretion of which is stimulated by certain prostaglandins. NSAIDs block the function of [[cyclooxygenase]] 1 (''cox-1''), which is essential for the production of these prostaglandins. Newer NSAIDs ([[celecoxib]], [[rofecoxib]]) only inhibit''cox-2'', which is less essential in the gastric mucosa, and roughly halve the risk of NSAID-related gastric ulceration.
+==Causes in Alphabetical Order==
-[[Tobacco smoking]], [[Blood type|blood group]], spices and other factors that were suspected to cause ulcers until late in the 20th century, are actually of relatively minor importance in the development of peptic ulcers.<ref>For nearly 100 years, scientists and doctors thought that ulcers were caused by stress, spicy food, and alcohol. Treatment involved bed rest and a bland diet. Later, researchers added stomach acid to the list of causes and began treating ulcers with antacids.[http://digestive.niddk.nih.gov/ddiseases/pubs/hpylori/ National Digestive Diseases Information Clearinghouse]</ref>
+*[[ABO blood group system|Blood group O]]
+*[[Burn (injury)|Burns]]
+*[[Family history (medicine)|Family history]]
+*[[Gastrinoma]]s
 *[[Glucocorticoid]]s
-*[[Burn (injury)|Burns]]
 *[[Head trauma]]
-*[[Mechanical ventilation]].
+*[[Mechanical ventilation]]
+*[[Overuse of laxatives]]
 *[[Tobacco smoking|Smoking]]
-*[[Overuse of laxatives]]
+*[[Zollinger-Ellison syndrome]]
-A [[Family history (medicine)|family history]] is often present in duodenal ulcers, especially when [[ABO blood group system|blood group O]] is also present. Inheritance appears to be unimportant in gastric ulcers.
-[[Gastrinoma]]s ([[Zollinger-Ellison syndrome]]), rare gastrin-secreting tumors, cause multiple and difficult to heal ulcers.
 ==References==
 {{reflist|2}}

Peptic ulcer causes: Difference between revisions

Revision as of 12:30, 19 August 2012

Contents

Overview

Comon Cuases

Causes in Alphabetical Order

References

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