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==[[Quinapril (patient information)|For patient information, click here]]== | ==[[Quinapril (patient information)|For patient information, click here]]== | ||
Revision as of 15:29, 20 August 2012
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| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 97% |
| Elimination half-life | 2 hours |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C25H30N2O5 |
| Molar mass | 438.516 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
For patient information, click here
Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.
Pharmacology
Quinapril is a prodrug. It is converted to its active metabolite, quinaprilat, in the liver.
Mechanism of action
Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
Indications
Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.
Contraindications
Side effects
Side effects of quinapril include dizziness, cough, vomiting, upset stomach and fatigue.
External links
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- Articles containing unverified chemical infoboxes
- ACE inhibitors
- Prodrugs
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