Staurosporine: Difference between revisions
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'''Staurosporine''' (antibiotic AM-2282) is a [[natural product]] originally isolated in 1977 from bacterium ''Streptomyces staurosporeus''. It was the first of over 50 [[alkaloid]]s to be isolated with this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray analysis of a single crystal and the absolute stereochemical configuration by the same method in 1994. | '''Staurosporine''' (antibiotic AM-2282) is a [[natural product]] originally isolated in 1977 from bacterium ''Streptomyces staurosporeus''. It was the first of over 50 [[alkaloid]]s to be isolated with this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray analysis of a single crystal and the absolute stereochemical configuration by the same method in 1994. | ||
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Latest revision as of 16:16, 20 August 2012
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C28H26N4O3 |
| Molar mass | 466.53 g/mol |
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US National Guidelines Clearinghouse on Staurosporine NICE Guidance on Staurosporine
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Patient resources on Staurosporine Discussion groups on Staurosporine Patient Handouts on Staurosporine Directions to Hospitals Treating Staurosporine Risk calculators and risk factors for Staurosporine
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Staurosporine (antibiotic AM-2282) is a natural product originally isolated in 1977 from bacterium Streptomyces staurosporeus. It was the first of over 50 alkaloids to be isolated with this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray analysis of a single crystal and the absolute stereochemical configuration by the same method in 1994.
Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive.[1] The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment.
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
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- E number from Wikidata
- ECHA InfoCard ID from Wikidata
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- Chemical pages without DrugBank identifier
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- Drugs missing an ATC code
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- Articles containing unverified chemical infoboxes
- Alkaloids
- Antibiotics