Tolbutamide: Difference between revisions
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'''Tolbutamide''' is a first generation potassium channel blocker, [[sulfonylurea]] [[anti-diabetic drug|oral hypoglycemic]] [[medication|drug]] sold under the brand name '''Orinase'''. This drug may be used in the management of [[type II diabetes]] if diet alone is not effective. Tolbutamide stimulates the secretion of [[insulin]] by the [[pancreas]]. Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of [[type I diabetes]]. It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as [[glyburide]]. | '''Tolbutamide''' is a first generation potassium channel blocker, [[sulfonylurea]] [[anti-diabetic drug|oral hypoglycemic]] [[medication|drug]] sold under the brand name '''Orinase'''. This drug may be used in the management of [[type II diabetes]] if diet alone is not effective. Tolbutamide stimulates the secretion of [[insulin]] by the [[pancreas]]. Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of [[type I diabetes]]. It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as [[glyburide]]. | ||
{{Oral hypoglycemics}} | {{Oral hypoglycemics}} | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
Revision as of 16:57, 20 August 2012
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| Pregnancy category | |
| Routes of administration | Oral (tablet) |
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| Pharmacokinetic data | |
| Protein binding | 96% |
| Metabolism | Hepatic (CYP2C19-mediated) |
| Elimination half-life | 4.5 to 6.5 hours |
| Excretion | Renal |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C12H18N2O3S |
| Molar mass | 270.349 g/mol |
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Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase. This drug may be used in the management of type II diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of type I diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as glyburide.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
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- Articles containing unverified chemical infoboxes
- Endocrinology
- Sulfonamides
- Sulfonylureas