Triamterene detailed information

Triamterene detailed information

Clinical data
ATC code	C03DB02 (WHO)
Pharmacokinetic data
Protein binding	97%
Identifiers
IUPAC name 6-phenylpteridine-2,4,7-triamine
CAS Number	396-01-0
PubChem CID	5546
DrugBank	APRD00079
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H11N7
Molar mass	253.263 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Triamterene (trade name Dyrenium) is a potassium-sparing diuretic used in combination with thiazide diuretics for the treatment of hypertension and edema. This medication is best avoided in patients with chronic kidney disease due to the possibility of hyperkalemia. People using this drug should use salt substitute very cautiously.

Mode of action

Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the principal cell and into the forming urine. Blocking ENaC prevents this from happening. Amiloride works in the same way.

Side effects

Common side effects may include a depletion of sodium, folic acid and calcium, nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause kidney stones through direct crystallization or by seeding calcium oxalate stones.