Trichostatin A: Difference between revisions
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'''Trichostatin A''' is an organic compound that serves as an antifungal antibiotic and selectively [[inhibitor|inhibits]] the mammalian [[histone deacetylase]] family of [[enzyme]]s. TSA inhibits the [[eukaryote|eukaryotic]] [[cell cycle]] during the beginning of the growth stage. TSA can be used to alter [[gene expression]] by interfering with the removal of [[acetyl]] groups from [[histones]] and therefore altering the ability of [[DNA]] [[transcription factors]] to access the DNA molecules inside [[chromatin]]. Thus, TSA has some uses as an anti-[[cancer]] drug. By promoting the expression of [[apoptosis]]-related [[gene]]s, it may lead to cancerous cells surviving at lower rates, thus slowing the progression of cancer. | '''Trichostatin A''' is an organic compound that serves as an antifungal antibiotic and selectively [[inhibitor|inhibits]] the mammalian [[histone deacetylase]] family of [[enzyme]]s. TSA inhibits the [[eukaryote|eukaryotic]] [[cell cycle]] during the beginning of the growth stage. TSA can be used to alter [[gene expression]] by interfering with the removal of [[acetyl]] groups from [[histones]] and therefore altering the ability of [[DNA]] [[transcription factors]] to access the DNA molecules inside [[chromatin]]. Thus, TSA has some uses as an anti-[[cancer]] drug. By promoting the expression of [[apoptosis]]-related [[gene]]s, it may lead to cancerous cells surviving at lower rates, thus slowing the progression of cancer. | ||
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[[Category:Antibiotics]] | [[Category:Antibiotics]] | ||
[[pl:Trichostatyna A]] | [[pl:Trichostatyna A]] | ||
Latest revision as of 17:05, 20 August 2012
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Trichostatin A is an organic compound that serves as an antifungal antibiotic and selectively inhibits the mammalian histone deacetylase family of enzymes. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. Thus, TSA has some uses as an anti-cancer drug. By promoting the expression of apoptosis-related genes, it may lead to cancerous cells surviving at lower rates, thus slowing the progression of cancer.