Ureidopenicillin: Difference between revisions
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The '''ureidopenicillins''' are a group of [[penicillin]]s which are active against ''[[Pseudomonas aeruginosa]]''. There are three ureidopenicillins in clinical use: | The '''ureidopenicillins''' are a group of [[penicillin]]s which are active against ''[[Pseudomonas aeruginosa]]''. There are three ureidopenicillins in clinical use: | ||
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[[Category:Beta-lactam antibiotics]] | [[Category:Beta-lactam antibiotics]] | ||
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Latest revision as of 17:13, 20 August 2012
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The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa. There are three ureidopenicillins in clinical use:
They are mostly ampicillin derivatives in which the D-side amino chain has been converted to a variety of ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.
They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria.