Drug allergy natural history, complications and prognosis: Difference between revisions
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
In general, any allergic reaction will worsen with continued exposure to the offending agent. [[Anaphylaxis]] will most certainly progress to death if untreated, and the same is true for the severe allergic reactions such as [[Stevens-Johnson syndrome]] and [[toxic epidermal necrolysis]]. | |||
==Natural History== | ==Natural History== | ||
*[[Stevens-Johnson syndrome]] starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane [[ulcerations]], [[conjunctivitis]], [[fever]], [[sore throat]], and [[fatigue]]. | *[[Stevens-Johnson syndrome]] starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane [[ulcerations]], [[conjunctivitis]], [[fever]], [[sore throat]], and [[fatigue]]. | ||
*[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | *[[Toxic epidermal necrolysis]] will progress similarly to [[Stevens-Johnson syndrome]], but will also cause large layers of the [[epidermis]] to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding. | ||
Revision as of 22:19, 20 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]
|
Drug Allergy |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Drug allergy natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Drug allergy natural history, complications and prognosis |
|
FDA on Drug allergy natural history, complications and prognosis |
|
CDC on Drug allergy natural history, complications and prognosis |
|
Drug allergy natural history, complications and prognosis in the news |
|
Blogs on Drug allergy natural history, complications and prognosis |
|
Risk calculators and risk factors for Drug allergy natural history, complications and prognosis |
Overview
In general, any allergic reaction will worsen with continued exposure to the offending agent. Anaphylaxis will most certainly progress to death if untreated, and the same is true for the severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
Natural History
- Stevens-Johnson syndrome starts with a generalized macropapular rash, that will then progress to bullae, mucous membrane ulcerations, conjunctivitis, fever, sore throat, and fatigue.
- Toxic epidermal necrolysis will progress similarly to Stevens-Johnson syndrome, but will also cause large layers of the epidermis to detatch from the layers below, leading to extreme amounts of sloughing of the skin surface, and an appearance of the skin that looks like burns or scalding.